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Mouse Anti-HSD17B7 (AA 255-341) Recombinant Antibody (CBFYH-2016) (CBMAB-H3027-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2016
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: NAFTLTPYNG TEALVWLFHQ KPESLNPLIK YLSATTGFGR NYIMTQKMDL DEDTAEKFYQ KLLELEKHIR VTIQKTDNQA RLSGSCL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 255-341

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 7
Introduction
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).
Entrez Gene ID
51478
UniProt ID
P56937
Alternative Names
Hydroxysteroid 17-Beta Dehydrogenase 7; Short Chain Dehydrogenase/Reductase Family 37C Member 1; 17-Beta-Hydroxysteroid Dehydrogenase 7; Estradiol 17-Beta-Dehydrogenase 7; 17-Beta-HSD 7; SDR37C1; Short Chain Dehydrogenase/Reductase Family 37C, Member 1; 17 Beta-Hydroxysteroid Dehydrogenase Type VII
Function
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030).

Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193).

Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030).

Isoform 3:
Does not have enzymatic activities toward E1 and DHT.
Biological Process
Androgen metabolic process Source: UniProtKB
Cholesterol biosynthetic process Source: UniProtKB
Estrogen biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Extracellular: 1-229
Helical: 230-250
Cytoplasmic: 251-341
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

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