Rabbit Anti-HSD17B6 Recombinant Antibody (CBFYH-2014) (CBMAB-H3026-FY)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBFYH-2014

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

hydroxysteroid 17-beta dehydrogenase 6

Introduction

The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family.

Entrez Gene ID

8630

UniProt ID

O14756

Alternative Names

Hydroxysteroid 17-Beta Dehydrogenase 6; Short Chain Dehydrogenase/Reductase Family 9C Member 6; Oxidative 3-Alpha-Hydroxysteroid-Dehydrogenase; 3(Alpha->Beta)-Hydroxysteroid Epimerasel; 3-Hydroxysteroid Epimerase; Retinol Dehydrogenase; 3-Alpha->Beta-HSE; Oxidoreductase; 17-Beta-HSD 6; EC 1.1.1.105; SDR9C6; RODH; NAD+ -Dependent 3 Alpha-Hydroxysteroid Dehydrogenase 3-Hydroxysteroid Epimerase; Hydroxysteroid (17-Beta) Dehydrogenase 6 Homolog (Mouse); Short Chain Dehydrogenase/Reductase Family 9C, Member 6; 17-Beta-Hydroxysteroid Dehydrogenase Type 6 Variant 1

Function

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.

Biological Process

Androgen biosynthetic process Source: UniProtKB
Androgen catabolic process Source: UniProtKB
Brexanolone catabolic process Source: UniProtKB

Cellular Location

Early endosome membrane; Microsome membrane

More Infomation

References

Wei, F., Gu, Y., He, L., Kapoor, A., Lin, X., Dong, Y., ... & Tang, D. (2023). HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation. Metabolism, 155631.

Tian, T., Hong, F., Wang, Z., Hu, J., Chen, N., Lv, L., & Yi, Q. (2021). HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma. Cell Death Discovery, 7(1), 341.

Stücheli, S. (2021). Investigating the Androgen Metabolizing Enzymes HSD17B6 & DHRS7 in Prostate Cancer (Doctoral dissertation, University_of_Basel).

Lv, L., Zhao, Y., Wei, Q., Zhao, Y., & Yi, Q. (2020). Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma. Cancer cell international, 20, 1-24.

Mares, L., Vilchis, F., Chávez, B., & Ramos, L. (2020). Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46, XY with hypospadias. Journal of Pediatric Urology, 16(5), 689-e1.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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