Mouse Anti-HPGDS Recombinant Antibody (L70B11) (CBMAB-G6014-LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Monkey

Clone

L70B11

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

hematopoietic prostaglandin D synthase

Introduction

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	27306
Mouse	54486
Rat	58962
Monkey	705227

UniProt ID

Human	O60760
Mouse	Q9JHF7
Rat	O35543
Monkey	F6Z1G0

Function

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Biological Process

Glutathione metabolic process Source: GO_Central
Locomotory behavior Source: ProtInc
Negative regulation of male germ cell proliferation Source: Ensembl
Prostaglandin biosynthetic process Source: UniProtKB-KW
Prostaglandin metabolic process Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cytoplasm

More Infomation

References

Yang, H., Fu, L., Li, L., Zhang, D., Li, Q., & Zhou, P. (2023). miR-665 overexpression inhibits the apoptosis of luteal cells in small ruminants suppressing HPGDS. Theriogenology, 206, 40-48.

Ouyang, L., Qiu, D., Fu, X., Wu, A., Yang, P., Yang, Z., ... & Xiao, R. (2022). Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice. Stem Cell Research & Therapy, 13(1), 1-15.v

Shao, F., Mao, H., Luo, T., Li, Q., Xu, L., & Xie, Y. (2022). HPGDS is a novel prognostic marker associated with lipid metabolism and aggressiveness in lung adenocarcinoma. Frontiers in Oncology, 12, 894485.

Huang, C., Ge, F., Ren, W., Zhang, Y., Wu, X., Zhang, Q., ... & Liang, C. (2021). Copy number variation of the HPGDS gene in the Ashidan yak and its associations with growth traits. Gene, 772, 145382.

Shao, Y. Y., Lin, F. U., Zhu, M. T., Ying, N. A. N., Heng, Y. A. N. G., & Zhao, Z. S. (2021). Mechanism of miR-665 Regulating Luteal Function Via Targeting HPGDS. KAFKAS ÜNİVERSİTESİ VETERİNER FAKÜLTESİ DERGİSİ, 27(6).

Chiba, Y., Suto, W., & Sakai, H. (2018). Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle tissues of experimental asthma. PLoS One, 13(8), e0202623.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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