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Mouse Anti-HOXC10 Recombinant Antibody (3F2) (CBMAB-A4054-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F2
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXC10 (AAH01293, 158 a.a. ~ 257 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox C10
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq]
Entrez Gene ID
3226
UniProt ID
Q9NYD6
Alternative Names
HOX3I; MGC5259
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Neuromuscular process Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system development Source: Ensembl
Spinal cord motor neuron cell fate specification Source: Ensembl
Cellular Location
Nucleus
More Infomation

Li, Y., Lei, H., Hai, R., Shu, G., Yan, W., & Yin, G. (2022). HOXC10 promotes carboplatin resistance of ovarian cancer by regulating ABCC3. American Journal of Cancer Research, 12(10), 4602.

Chen, Z., Wu, J., Liu, B., Zhang, G., Wang, Z., Zhang, L., ... & Zhu, P. (2021). Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations. Cell Reports, 36(4).

Fang, J., Wang, J., Yu, L., & Xu, W. (2021). Role of HOXC10 in Cancer. Frontiers in Oncology, 11, 684021.

Suo, D., Wang, Z., Li, L., Chen, Q., Zeng, T., Liu, R., ... & Li, Y. (2020). HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis. Oncogene, 39(32), 5441-5454.

Enteghami, M., Ghorbani, M., Zamani, M., & Galehdari, H. (2020). HOXC10 is significantly overexpressed in colorectal cancer. Biomedical reports, 13(3), 1-1.

Dang, Y., Chen, J., Feng, W., Qiao, C., Han, W., Nie, Y., ... & Xia, L. (2020). Interleukin 1β-mediated HOXC10 overexpression promotes hepatocellular carcinoma metastasis by upregulating PDPK1 and VASP. Theranostics, 10(8), 3833.

Peng, Y., Li, Y., Li, Y., Wu, A., Fan, L., Huang, W., ... & Yin, G. (2020). HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer. Aging (Albany NY), 12(19), 19375.

Kim, J., Bae, D. H., Kim, J. H., Song, K. S., Kim, Y. S., & Kim, S. Y. (2019). HOXC10 overexpression promotes cell proliferation and migration in gastric cancer. Oncology reports, 42(1), 202-212.

Dai, B. W., Yang, Z. M., Deng, P., Chen, Y. R., He, Z. J., Yang, X., ... & Ren, Z. H. (2019). HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. Journal of Cancer, 10(19), 4540.

Tan, Z., Chen, K., Wu, W., Zhou, Y., Zhu, J., Wu, G., ... & Li, J. (2018). Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression. Theranostics, 8(18), 5143.

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For research use only. Not intended for any clinical use.

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