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Mouse Anti-HOXB5 Recombinant Antibody (3F10) (CBMAB-A4041-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXB5 (NP_002138.1, 170 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
HOXB5
Introduction
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq]
Entrez Gene ID
3215
UniProt ID
P09067
Alternative Names
HHO.C10; HOX2; HOX2A; HU-1; Hox2.1
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Endothelial cell differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
More Infomation

Zhang, J., Zhang, S., Li, X., Zhang, F., & Zhao, L. (2021). HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway. Pathology-Research and Practice, 224, 153117.

Sakamaki, T., Kao, K. S., Nishi, K., Chen, J. Y., Sadaoka, K., Fujii, M., ... & Miyanishi, M. (2021). Hoxb5 defines the heterogeneity of self-renewal capacity in the hematopoietic stem cell compartment. Biochemical and Biophysical Research Communications, 539, 34-41.

Chen, M., Qu, Y., Yue, P., & Yan, X. (2021). The prognostic value and function of HOXB5 in acute myeloid leukemia. Frontiers in Genetics, 12, 678368.

Feng, W., Huang, W., Chen, J., Qiao, C., Liu, D., Ji, X., ... & Xia, L. (2021). CXCL12-mediated HOXB5 overexpression facilitates colorectal cancer metastasis through transactivating CXCR4 and ITGB3. Theranostics, 11(6), 2612.

Lee, K., Chang, J. W., Oh, C., Liu, L., Jung, S. N., Won, H. R., ... & Koo, B. S. (2020). HOXB5 acts as an oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin signaling axis. European Journal of Surgical Oncology, 46(6), 1066-1073.

Li, Z. X., Wu, G., Jiang, W. J., Li, J., Wang, Y. Y., Ju, X. M., & Yin, Y. T. (2020). HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway. Cell Cycle, 19(2), 233-245.

Xu, H., Zhao, H., & Yu, J. (2018). HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production. American Journal of Translational Research, 10(6), 1703.

Zhang, B., Li, N., & Zhang, H. (2018). Knockdown of homeobox B5 (HOXB5) inhibits cell proliferation, migration, and invasion in non-small cell lung cancer cells through inactivation of the Wnt/β-catenin pathway. Oncology research, 26(1), 37.

Lee, J. Y., Kim, J. M., & Kim, M. H. (2018). Transcriptional activation of EGFR by HOXB5 and its role in breast cancer cell invasion. Biochemical and biophysical research communications, 503(4), 2924-2930.

Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., ... & Wang, J. (2018). Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nature immunology, 19(3), 279-290.

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For research use only. Not intended for any clinical use.

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