Mouse Anti-HOXB1 Recombinant Antibody (CBFYH-1755) (CBMAB-H0716-FY)

Name: Mouse Anti-HOXB1 Recombinant Antibody (CBFYH-1755)
SKU: CBMAB-H0716-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-1755

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Homeobox B1

Introduction

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.

Entrez Gene ID

3211

UniProt ID

P14653

Alternative Names

Homeobox B1; Homeobox Protein Hox-2I; HOX2I; Homeobox Protein Hox-B1; Homeo Box B1; Hox-2.9; HCFP3; HOX2

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Biological Process

Anatomical structure formation involved in morphogenesis Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Facial nerve structural organization Source: Ensembl
Facial nucleus development Source: Ensembl
Pattern specification process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhombomere 4 development Source: Ensembl
Rhombomere 5 development Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Facial paresis, hereditary congenital, 3 (HCFP3):
A form of facial paresis, a disease characterized by isolated dysfunction of the facial nerve (CN VII). HCFP3 patients are affected by bilateral facial palsy, facial muscle weakness of muscles innervated by CN VII, hearing loss, and strabismus.

More Infomation

References

Chen, C. H., & Behringer, R. R. (2022). Transgenic human HOXB1-9 directs anterior-posterior axial skeleton pattern in Hoxb1-9 deficient mice. Differentiation, 127, 1-11.

Pazur, K., Giannios, I., Lesche, M., Rodriguez-Aznar, E., & Gavalas, A. (2022). Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification. Stem Cells, 40(2), 175-189.

Singh, N. P., De Kumar, B., Paulson, A., Parrish, M. E., Scott, C., Zhang, Y., ... & Krumlauf, R. (2021). Genome-wide binding analyses of HOXB1 revealed a novel DNA binding motif associated with gene repression. Journal of developmental biology, 9(1), 6.

Cui, F., Zhou, Q., Xiao, K., & Ma, S. (2020). The microRNA hsa-let-7g promotes proliferation and inhibits apoptosis in lung cancer by targeting HOXB1. Yonsei Medical Journal, 61(3), 210-217.

Zhou, J. L., Deng, S., Fang, H. S., Yu, G., & Peng, H. (2019). Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway. Biomedicine & Pharmacotherapy, 109, 2335-2341.

Zaffran, S., Odelin, G., Stefanovic, S., Lescroart, F., & Etchevers, H. C. (2018). Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. Genesis, 56(6-7), e23221.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

HOXB1 Matched Antibody Pair (565)

Related Products

HOXB1 Matched Antibody Pair (565)

Mouse Anti-HOXB1 Recombinant Antibody (CBFYH-1758)

Mouse Anti-HOXB1 Recombinant Antibody (1E2)

Mouse Anti-HOXB1 Recombinant Antibody (3F9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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