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Mouse Anti-HOMER2 Recombinant Antibody (CBFYH-1693) (CBMAB-H2699-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1693
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human HOMER2 produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Homer Scaffolding Protein 2
Introduction
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14.
Entrez Gene ID
9455
UniProt ID
Q9NSB8
Alternative Names
Homer Scaffolding Protein 2; HOMER-2; Cupidin; Homer, Neuronal Immediate Early Gene, 2; Homer Homolog 2 (Drosophila); Homer Protein Homolog 2; Homer Homolog 2
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459).

Required for normal hearing (PubMed:25816005).

Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Biological Process
Behavioral response to cocaine Source: Ensembl
Calcium-mediated signaling using intracellular calcium source Source: Ensembl
Chemical homeostasis within a tissue Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Regulation of G protein-coupled receptor signaling pathway Source: Ensembl
Regulation of store-operated calcium entry Source: GO_Central
Sensory perception of sound Source: UniProtKB
Cellular Location
Cytoplasm; Cell membrane; Postsynaptic density; Synapse; Stereocilium. Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Involvement in disease
Deafness, autosomal dominant, 68 (DFNA68):
A form of non-syndromic sensorineural hearing loss with postlingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
More Infomation

Szumlinski, K. K., Beltran, J., van Doren, E., Chavez, C. L. J., Domingo-Gonzalez, R. D., Reyes, C. M., ... & Huber, K. M. (2023). Evidence for phosphorylation-dependent, dynamic, regulation of mGlu5 and Homer2 in expression of cocaine aversion in mice. eneuro, 10(4).

Luo, P., Liang, C., Jing, W., Zhu, M., Zhou, H., Chai, H., ... & Tu, J. (2021). Homer2 and Homer3 act as novel biomarkers in diagnosis of hepatitis B virus-induced hepatocellular carcinoma. Journal of Cancer, 12(12), 3439.

Huang, G., Thompson, S. L., & Taylor, J. R. (2021). MPEP lowers binge drinking in male and female C57BL/6 mice: relationship with mGlu5/Homer2/Erk2 signaling. Alcoholism: Clinical and Experimental Research, 45(4), 732-742.

Lorenzon, P., Furlan, S., Ravara, B., Bosutti, A., Massaria, G., Bernareggi, A., ... & Volpe, P. (2021). Preliminary observations on skeletal muscle adaptation and plasticity in homer 2-/-mice. Metabolites, 11(9), 642.

Blottner, D., Trautmann, G., Furlan, S., Gambara, G., Block, K., Gutsmann, M., ... & Salanova, M. (2021). Reciprocal homer1a and homer2 isoform expression is a key mechanism for muscle soleus atrophy in spaceflown mice. International journal of molecular sciences, 23(1), 75.

Lachgar, M., Morín, M., Villamar, M., Del Castillo, I., & Moreno-Pelayo, M. Á. (2021). A novel truncating mutation in HOMER2 causes nonsyndromic progressive DFNA68 hearing loss in a Spanish family. Genes, 12(3), 411.

Brown, C. N., Fultz, E. K., Ferdousian, S., Rogers, S., Lustig, E., Page, A., ... & Szumlinski, K. K. (2020). Transgenic analyses of Homer2 function within nucleus accumbens subregions in the regulation of methamphetamine reward and reinforcement in mice. Frontiers in psychiatry, 11, 11.

Son, A., Kang, N., Oh, S. Y., Kim, K. W., Muallem, S., Yang, Y. M., & Shin, D. M. (2019). Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism. Journal of Endocrinology, 242(3), 241-249.

Lu, X., Wang, Q., Gu, H., Zhang, X., Qi, Y., & Liu, Y. (2018). Whole exome sequencing identified a second pathogenic variant in HOMER2 for autosomal dominant non‐syndromic deafness. Clinical Genetics, 94(5), 419-428.

Lee, K. M., Coelho, M. A., Sern, K. R., & Szumlinski, K. K. (2018). Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking. Neuropharmacology, 128, 448-459.

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For research use only. Not intended for any clinical use.

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