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Mouse Anti-HOMER1 Recombinant Antibody (AT1F3) (CBMAB-H2692-FY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
AT1F3
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
homer homolog 1 (Drosophila)
Introduction
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
Entrez Gene ID
9456
UniProt ID
Q86YM7
Alternative Names
Homer Scaffolding Protein 1; Homer-1; SYN47; Homer, Neuronal Immediate Early Gene, 1; Homer Homolog 1 (Drosophila); Homer Protein Homolog 1; Homer Homolog 1
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).

Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Biological Process
Behavioral response to cocaine Source: Ensembl
Chemical homeostasis within a tissue Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Circadian rhythm Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: ProtInc
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of signal transduction Source: BHF-UCL
Protein localization to synapse Source: Ensembl
Protein tetramerization Source: UniProtKB
Regulation of calcium ion import Source: Ensembl
Regulation of cation channel activity Source: BHF-UCL
Regulation of dendritic spine maintenance Source: UniProtKB
Regulation of postsynaptic neurotransmitter receptor activity Source: Ensembl
Regulation of store-operated calcium entry Source: GO_Central
Regulation of synaptic transmission, glutamatergic Source: UniProtKB
Response to calcium ion Source: BHF-UCL
Response to nicotine Source: Ensembl
Skeletal muscle contraction Source: Ensembl
Skeletal muscle fiber development Source: Ensembl
Cellular Location
Cytoplasm; Postsynaptic density; Synapse; Dendritic spine. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
More Infomation

de Bartolomeis, A., Barone, A., Buonaguro, E. F., Tomasetti, C., Vellucci, L., & Iasevoli, F. (2022). The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A systematic review and translational insight. Neuroscience & Biobehavioral Reviews, 136, 104596.

Fei, X., Dou, Y. N., Wang, L., Wu, X., Huan, Y., Wu, S., ... & Fei, Z. (2022). Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage. Journal of Neuroinflammation, 19(1), 1-18.

Liu, C. Y., Chen, J. B., Liu, Y. Y., Zhou, X. M., Zhang, M., Jiang, Y. M., ... & Chen, J. X. (2022). Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress. Chinese Medicine, 17(1), 60.

Yoon, S., Piguel, N. H., Khalatyan, N., Dionisio, L. E., Savas, J. N., & Penzes, P. (2021). Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome. Molecular psychiatry, 26(6), 1775-1789.

Urdánoz-Casado, A., Sánchez-Ruiz de Gordoa, J., Robles, M., Acha, B., Roldan, M., Zelaya, M. V., ... & Mendioroz, M. (2021). Gender-dependent deregulation of linear and circular RNA variants of HOMER1 in the entorhinal cortex of Alzheimer’s disease. International Journal of Molecular Sciences, 22(17), 9205.

Reshetnikov, V. V., & Bondar, N. P. (2021). The role of stress-induced changes of Homer1 expression in stress susceptibility. Biochemistry (Moscow), 86(6), 613-626.

Zhao, M., Dong, G., Meng, Q., Lin, S., & Li, X. (2020). Circ‐HOMER1 enhances the inhibition of miR‐1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells. Journal of Cellular Biochemistry, 121(11), 4440-4449.

Li, M. X., Li, Q., Sun, X. J., Luo, C., Li, Y., Wang, Y. N., ... & Chen, H. (2019). Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 95, 109682.

Rybchyn, M. S., Islam, K. S., Brennan-Speranza, T. C., Cheng, Z., Brennan, S. C., Chang, W., ... & Conigrave, A. D. (2019). Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts. Journal of Biological Chemistry, 294(44), 16337-16350.

Benedetti, F., Poletti, S., Locatelli, C., Mazza, E., Lorenzi, C., Vitali, A., ... & Colombo, C. (2018). A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: a multimodal genetic imaging study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 81, 88-95.

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For research use only. Not intended for any clinical use.

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