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Rabbit Anti-HNMT Recombinant Antibody (CBFYH-1613) (CBMAB-H2608-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYH-1613
Antibody Isotype
IgG
Application
ELISA, WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
histamine N-methyltransferase
Introduction
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Entrez Gene ID
3176
UniProt ID
P50135
Alternative Names
Histamine N-Methyltransferase; EC 2.1.1.8; HMT; HNMT-S1; HNMT-S2; MRT51
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Biological Process
Histamine catabolic process Source: UniProtKB
Histamine metabolic process Source: ARUK-UCL
Histidine catabolic process Source: Reactome
Methylation Source: UniProtKB
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 51 (MRT51):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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