Rabbit Anti-HMOX2 Recombinant Antibody (CBFYH-1584) (CBMAB-H2570-FY)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat, Hamster, Monkey

Clone

CBFYH-1584

Application

Basic Information

Specificity

Human, Mouse, Rat, Hamster, Monkey

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Heme Oxygenase 2

Introduction

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene.

Entrez Gene ID

Human	3163
Mouse	15369
Rat	79239
Hamster	101844419
Monkey	705461

UniProt ID

Human	P30519
Mouse	O70252
Rat	P23711
Hamster	A0A1U8CNW1
Monkey	I0FKU7

Alternative Names

Heme Oxygenase 2; Heme Oxygenase (Decycling) 2; HO-2; EC 1.14.14.18; EC 1.14.99.3; HO2

Function

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Biological Process

Heme catabolic process Source: GO_Central
Heme oxidation Source: GO_Central
Iron ion homeostasis Source: GO_Central
Response to hypoxia Source: UniProtKB
Response to oxidative stress Source: GO_Central

Cellular Location

Microsome; Endoplasmic reticulum

More Infomation

References

Lin, A., Kong, M., Gu, W., Moya, E., Lawrence, E., Yu, J., & Simonson, T. (2023). Identification of HMOX2 promoter variants linked to adaptation in Tibetans. Physiology, 38(S1), 5733952.

Fabries, P., Drogou, C., Sauvet, F., Nespoulous, O., Erkel, M. C., Marchandot, V., ... & Chennaoui, M. (2022). The HMOX2 polymorphism contributes to the carotid body chemoreflex in European sea-level residents by regulating hypoxic ventilatory responses. Frontiers in Medicine, 9, 1000786.

Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.

He, J., Liu, X., Li, S., Wang, J., Hu, J., & Luo, Y. (2018). Cloning, expression and hypoxia adaptation evolution of HMOX2 gene in Tibetan sheep (Ovis aries). Journal of Agricultural Biotechnology, 26(11), 1890-1899.

Yip, G., Heinrich, E. C., Villafuerte, F. C., & Simonson, T. S. (2018). Heme‐oxygenase 2 (HMOX2) variants associated with evolutionary adaptation and hemoglobin concentration in Tibetans are common in Andean Highlanders. The FASEB Journal, 32, lb413-lb413.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

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SDS
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Second antibody and isotype control

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