Mouse Anti-HMGXB4 (AA 1-74) Recombinant Antibody (CBFYH-1558) (CBMAB-H2539-FY)

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Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-1558

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ VRNSSKKKLK DSELYFLGTD THKK

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-74

Target

Full Name

HMGXB4

Introduction

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.

Entrez Gene ID

10042

UniProt ID

Q9UGU5

Alternative Names

HMG-Box Containing 4; High Mobility Group Protein 2-Like 1; HMG Box-Containing Protein 4; HMG Box Domain Containing 4; HMG2L1; HMGBCG

Function

Negatively regulates Wnt/beta-catenin signaling during development.

Biological Process

Endosome to lysosome transport Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Nucleus

More Infomation

References

Devaraj, A., Singh, M., Narayanavari, S. A., Yong, G., Chen, J., Wang, J., ... & Izsvák, Z. (2023). HMGXB4 targets Sleeping Beauty transposition to germinal stem cells. International Journal of Molecular Sciences, 24(8), 7283.

He, X., Dong, K., Shen, J., Hu, G., Liu, J., Kang, X., ... & Zhou, J. (2021). Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. Proceedings of the National Academy of Sciences, 118(7), e2021862118.

He, X., Dong, K., Shen, J., Osman, I., Hu, G., & Zhou, J. (2020). The Novel High Mobility Group Protein Hmgxb4 Promotes Neointimal Formation in Response to Arterial Injury. Circulation, 142(Suppl_3), A15691-A15691.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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