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Rabbit Anti-HCLS1 Recombinant Antibody (CBFYH-3539) (CBMAB-H4091-FY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
CBFYH-3539
Antibody Isotype
IgG
Application
WB, IP, IHC-P, FC

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hematopoietic cell-specific Lyn substrate 1
Introduction
HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1) is a Protein Coding gene. Diseases associated with HCLS1 include Spherocytosis, Type 1 and Congenital Hemolytic Anemia. Among its related pathways are Development Slit-Robo signaling and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is CTTN.
Entrez Gene ID
Mouse15163
Rat288077
UniProt ID
MouseP49710
RatQ68FX4
Alternative Names
HS1; AW213261
Function
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Biological Process
Actin filament polymerization Source: InterPro
Cellular response to cytokine stimulus Source: BHF-UCL
Erythrocyte differentiation Source: UniProtKB
Intracellular signal transduction Source: ProtInc
Negative regulation of leukocyte apoptotic process Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of granulocyte differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein import into nucleus Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Regulation of actin filament polymerization Source: BHF-UCL
Regulation of transcription, DNA-templated Source: ProtInc
Response to hormone Source: UniProtKB
Cellular Location
Mitochondrion; Cytoplasm; Membrane
PTM
Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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