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Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0747) (CBMAB-H0355-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0747
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HB-EGF, Asp63-Leu148
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heparin-binding EGF-like growth factor
Introduction
HBEGF (Heparin Binding EGF Like Growth Factor) is a Protein Coding gene. Diseases associated with HBEGF include Diphtheria and Bladder Disease. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is AREG.
Entrez Gene ID
1839
UniProt ID
Q99075
Alternative Names
Heparin Binding EGF Like Growth Factor; Diphtheria Toxin Receptor (Heparin-Binding Epidermal Growth Factor-Like Growth Factor); Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor); Heparin-Binding Epidermal Growth Factor; HEGFL; DTR
Function
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Biological Process
Cell chemotaxis Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
Muscle organ development Source: ProtInc
Negative regulation of elastin biosynthetic process Source: Ensembl
Positive regulation of cell growth Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of keratinocyte migration Source: Ensembl
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of wound healing Source: BHF-UCL
Regulation of heart contraction Source: Ensembl
Signal transduction Source: ProtInc
Wound healing, spreading of epidermal cells Source: Ensembl
Cellular Location
Heparin-binding EGF-like growth factor: Extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Proheparin-binding EGF-like growth factor: Cell membrane
Topology
Extracellular: 20-160
Helical: 161-184
Cytoplasmic: 185-208
PTM
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.
More Infomation

Kim, Y. S., Yuan, J., Dewar, A., Borg, J. P., Threadgill, D. W., Sun, X., & Dey, S. K. (2023). An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation. Proceedings of the National Academy of Sciences, 120(20), e2302937120.

Zhou, L., Zhou, W., Joseph, A. M., Chu, C., Putzel, G. G., Fang, B., ... & Sonnenberg, G. F. (2022). Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature immunology, 23(2), 251-261.

Yi, L., Ai, K., Li, H., Qiu, S., Li, Y., Wang, Y., ... & Zhang, D. (2021). CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis. Aging (Albany NY), 13(9), 12780.

Li, Y., Su, G., Zhong, Y., Xiong, Z., Huang, T., Quan, J., ... & Lai, T. (2021). HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration. BMC Pulmonary Medicine, 21(1), 1-12.

Rao, L., Giannico, D., Leone, P., Solimando, A. G., Maiorano, E., Caporusso, C., ... & Racanelli, V. (2020). HB-EGF–EGFR signaling in bone marrow endothelial cells mediates angiogenesis associated with multiple myeloma. Cancers, 12(1), 173.

Fu, E., Liu, T., Yu, S., Chen, X., Song, L., Lou, H., ... & Wei, L. (2020). M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB‑EGF. Oncology Reports, 44(2), 698-710.

Eapen, M. S., Sharma, P., Thompson, I. E., Lu, W., Myers, S., Hansbro, P. M., & Sohal, S. S. (2019). Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Laboratory Investigation, 99(2), 150-157.

Wen, H. J., Gao, S., Wang, Y., Ray, M., Magnuson, M. A., Wright, C. V., ... & Crawford, H. C. (2019). Myeloid cell-derived HB-EGF drives tissue recovery after pancreatitis. Cellular and Molecular Gastroenterology and Hepatology, 8(2), 173-192.

Yang, C. C., & Chang, K. W. (2018). Eicosanoids and HB-EGF/EGFR in cancer. Cancer and Metastasis Reviews, 37, 385-395.

Wang, H. U. I., Shi, G., Li, M., Fan, H., Ma, H., & Sheng, L. I. (2018). Correlation of IL-1 and HB-EGF with endometrial receptivity. Experimental and therapeutic medicine, 16(6), 5130-5136.

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For research use only. Not intended for any clinical use.

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