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Mouse Anti-GZMH Recombinant Antibody (185813) (CBMAB-G1016-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
185813
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Granzyme H, Glu19-Leu246, Accession # P20718
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
granzyme H
Introduction
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
Entrez Gene ID
2999
UniProt ID
P20718
Alternative Names
Granzyme H; Cathepsin G-Like 2; Protein H-CCPX; Cytotoxic T-Lymphocyte Proteinase; CTSGL2; CCP-X; CSP-C; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Granzyme H (Cathepsin G-Like 2; Protein H-CCPX); Cytotoxin Serine Protease-C;
Function
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Biological Process
Apoptotic process Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Cellular Location
Cytolytic granule
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For research use only. Not intended for any clinical use.

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