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Mouse Anti-GPC4 (AA 401-529) Recombinant Antibody (CBFYH-0437) (CBMAB-H1310-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0437
Antibody Isotype
IgG2a, κ
Application
WB, FC, ELISA, IF

Basic Information

Immunogen
Recombinant human GPC4 purified from E. coli
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 401-529

Target

Full Name
glypican 4
Introduction
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Entrez Gene ID
2239
UniProt ID
O75487
Alternative Names
Glypican 4; Glypican Proteoglycan 4; K-Glypican; DJ900E8.1 (Glypican 4); Glypican-4
Function
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).
Biological Process
Cell migration Source: GO_Central
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: GO_Central
Regulation of presynapse assembly Source: GO_Central
Regulation of protein localization to membrane Source: GO_Central
Regulation of signal transduction Source: InterPro
Synaptic membrane adhesion Source: GO_Central
Wnt signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Secreted glypican-4: Extracellular space
Involvement in disease
Keipert syndrome (KPTS):
An X-linked recessive syndrome characterized by craniofacial and digital abnormalities. Clinical features include a prominent forehead, a flat midface, hypertelorism, a broad nose, downturned corners of mouth, and widening of all distal phalanges. Additional variable features are cognitive impairment and sensorineural deafness.
More Infomation

Saroja, S. R., Gorbachev, K., TCW, J., Goate, A. M., & Pereira, A. C. (2022). Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. Proceedings of the National Academy of Sciences, 119(34), e2108870119.

Muendlein, A., Brandtner, E. M., Leiherer, A., Geiger, K., Heinzle, C., Gaenger, S., ... & Drexel, H. (2022). Evaluation of the association of serum glypican-4 with prevalent and future kidney function. Scientific Reports, 12(1), 1-8.

Muendlein, A., Brandtner, E. M., Leiherer, A., Geiger, K., Heinzle, C., Gaenger, S., ... & Drexel, H. (2022). Data on the association of serum glypican-4 with future major adverse cardiovascular events and mortality in patients undergoing coronary angiography. Data in Brief, 42, 108142.

Muendlein, A., Brandtner, E. M., Leiherer, A., Geiger, K., Heinzle, C., Gaenger, S., ... & Drexel, H. (2022). Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients. Atherosclerosis, 345, 33-38.

Hu, B., Rodriguez, J. J., Kakkerla Balaraju, A., Gao, Y., Nguyen, N. T., Steen, H., ... & Lin, F. (2021). Glypican 4 mediates Wnt transport between germ layers via signaling filopodia. Journal of Cell Biology, 220(12), e202009082.

Ma, K., Xing, S., Luan, Y., Zhang, C., Liu, Y., Fei, Y., ... & Chen, X. (2021). Glypican 4 regulates Aβ internalization in neural stem cells partly via low-density lipoprotein receptor-related protein 1. Frontiers in Cellular Neuroscience, 15, 732429.

Munir, J., Van Ngu, T., Ayudthaya, P. D. N., & Ryu, S. (2020). Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation. Biochemical and Biophysical Research Communications, 526(1), 91-97.

Hu, B., Gao, Y., Davies, L., Woo, S., Topczewski, J., Jessen, J. R., & Lin, F. (2018). Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development, 145(17), dev163303.

Dowling, C., & Allen, N. J. (2018). Mice lacking glypican 4 display juvenile hyperactivity and adult social interaction deficits. Brain Plasticity, 4(2), 197-209.

Cao, J., Ma, J., Sun, L., Li, J., Qin, T., Zhou, C., ... & Han, L. (2018). Targeting glypican‐4 overcomes 5‐FU resistance and attenuates stem cell–like properties via suppression of Wnt/β‐catenin pathway in pancreatic cancer cells. Journal of cellular biochemistry, 119(11), 9498-9512.

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For research use only. Not intended for any clinical use.

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