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Mouse Anti-GOLGA5 Recombinant Antibody (CBLG1-1475) (CBMAB-G4273-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1475
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Golgin A5
Introduction
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]
Entrez Gene ID
9950
UniProt ID
Q8TBA6
Alternative Names
Golgin A5; Cell Proliferation-Inducing Gene 31 Protein; Golgi Autoantigen; Golgin Subfamily A; 5; Golgi Integral Membrane Protein 5; RET-Fused Gene 5 Protein; Golgin-84; RFG5;
Function
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
Biological Process
Golgi organization Source: UniProtKB
Golgi vesicle transport Source: UniProtKB
Retrograde transport, vesicle recycling within Golgi Source: GO_Central
Cellular Location
Golgi apparatus membrane. Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.
Involvement in disease
A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene.
Topology
Cytoplasmic: 2-698
Helical: 699-719
Lumenal: 720-731
PTM
Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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