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Mouse Anti-GNRH1 Recombinant Antibody (CBLG1-1438) (CBMAB-G4199-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1438
Antibody Isotype
IgG1
Application
ELISA, IHC, RIA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Gonadotropin Releasing Hormone 1
Introduction
This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
Entrez Gene ID
2796
UniProt ID
P01148
Alternative Names
GNRH; GRH; LHRH; LNRH
Function
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Biological Process
Aging Source: Ensembl
Cell-cell signaling Source: ProtInc
Estrous cycle Source: Ensembl
Female pregnancy Source: Ensembl
Male sex determination Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of immature T cell proliferation Source: Ensembl
Negative regulation of neuron migration Source: Ensembl
Regulation of gene expression Source: Ensembl
Regulation of ovarian follicle development Source: Ensembl
Reproduction Source: GO_Central
Response to corticosteroid Source: Ensembl
Response to ethanol Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to potassium ion Source: Ensembl
Response to prolactin Source: Ensembl
Response to prostaglandin E Source: Ensembl
Response to testosterone Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Hypogonadotropic hypogonadism 12 with or without anosmia (HH12):
The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in GNRH1 as well as in other HH-associated genes including PROKR2 and FGFR1 (PubMed:23643382). A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
More Infomation

Cho-Clark, M. J., Watkins, A., & Wu, T. J. (2023). The role of GnRH metabolite, GnRH-(1-5), in endometrial cancer. Frontiers in Endocrinology, 14.

Patil, V. A., Lila, A. R., Shah, N., Ekbote, A. V., Shah, R., Bhandare, V. V., ... & Bandgar, T. (2022). GNRH1 Variants in Congenital Hypogonadotropic Hypogonadism: Single-Center Experience and Systematic Literature Review. Neuroendocrinology, 112(8), 723-732.

Li, C., Han, T., Li, Q., Zhang, M., Guo, R., Yang, Y., ... & Hu, R. (2021). MKRN3-mediated ubiquitination of Poly (A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty. Nucleic Acids Research, 49(7), 3796-3813.

Petrucci, L., Maranesi, M., Supplizi, A. V., Dall’Aglio, C., Mandara, M. T., Quassinti, L., ... & Zerani, M. (2020). Kisspeptin/GnRH1 system in Leydig cells of horse (Equus caballus): Presence and function. Theriogenology, 152, 1-7.

Taroc, E. Z. M., Naik, A. S., Lin, J. M., Peterson, N. B., Keefe, D. L., Genis, E., ... & Forni, P. E. (2020). Gli3 regulates vomeronasal neurogenesis, olfactory ensheathing cell formation, and GnRH-1 neuronal migration. Journal of Neuroscience, 40(2), 311-326.

Taroc, E. Z. M., Katreddi, R. R., & Forni, P. E. (2020). Identifying Isl1 genetic lineage in the developing olfactory system and in GnRH-1 neurons. Frontiers in Physiology, 11, 601923.

Li, X., Xiao, J., Fan, Y., Yang, K., Li, K., Wang, X., ... & Zhou, Y. (2019). miR-29 family regulates the puberty onset mediated by a novel Gnrh1 transcription factor TBX21. Journal of Endocrinology, 242(3), 185-197.

Yellapragada, V., Liu, X., Lund, C., Känsäkoski, J., Pulli, K., Vuoristo, S., ... & Raivio, T. (2019). MKRN3 interacts with several proteins implicated in puberty timing but does not influence GNRH1 expression. Frontiers in endocrinology, 10, 48.

Taroc, E. Z. M., Lin, J. M., Tulloch, A. J., Jaworski, A., & Forni, P. E. (2019). GnRH-1 neural migration from the nose to the brain is independent from Slit2, Robo3 and NELL2 signaling. Frontiers in Cellular Neuroscience, 13, 70.

Elokil, A. A., Bhuiyan, A. A., Liu, H. Z., Hussein, M. N., Ahmed, H. I., Azmal, S. A., ... & Li, S. (2019). The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2. Poultry Science, 98(9), 4172-4181.

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For research use only. Not intended for any clinical use.

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