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Rabbit Anti-GJA3 Recombinant Antibody (11H16L33) (CBMAB-0347CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
11H16L33
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Synthetic peptide from Mouse GJA3 aa 131-144
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
gap junction protein alpha 3
Introduction
Gap junctions are made up of 2 interacting hemichannels that form communicating channels between neighboring cells. Each hemichannel contains 6 connexin subunits. GJA3 is a connexin of the ocular lens, where gap junctions maintain ionic and water balance and the transparency and optical properties of the lens. The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). Using coimmunoprecipitation analysis, Nielsen et al. (2003) found that Cx46 and Cx50 (GJA8; 600897) interacted with the tight junction protein Zo1 (TJP1; 601009) in mouse lens fiber cells. Mutation analysis revealed that the second PDZ domain of Zo1 interacted with C-terminal isoleucines of Cx46 and Cx50.
Entrez Gene ID
14611
UniProt ID
Q64448
Alternative Names
Cx43; Cx46; Cnx46; Gja-3
Function
Structural component of lens fiber gap junctions (PubMed:30044662).

Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity).

They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:30044662).
Biological Process
Cell-cell signaling Source: GO_Central
Gap junction-mediated intercellular transport Source: UniProtKB
Visual perception Source: InterPro
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Cataract 14, multiple types (CTRCT14):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT14 includes zonular pulverulent cataract, among others. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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