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Rabbit Anti-GALP Recombinant Antibody (BA0088) (CBMAB-0326CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0088
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide aa 50 to the C-terminus (Cysteine residue)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Galanin Like Peptide
Introduction
GALP is a galanin (GAL; 137035)-like peptide that displays preferential binding and activation of galanin receptor-2. This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. Hartz (2007) mapped the GALP gene to chromosome 19q13.42 based on an alignment of the GALP sequence (GenBank AF188492) with the genomic sequence. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.
Entrez Gene ID
85569
UniProt ID
Q9UBC7
Alternative Names
Galanin Like Peptide; Gal-Like Peptide; Alarin
Function
Isoform 1:
Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.

Isoform 2:
Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (PubMed:23537644).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Behavioral response to starvation Source: GO_Central
Defense response to Gram-negative bacterium Source: UniProtKB
Modulation of process of other organism Source: UniProtKB
Neuropeptide signaling pathway Source: UniProtKB-KW
Regulation of appetite Source: Ensembl
Response to insulin Source: Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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