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Mouse Anti-GAL Recombinant Antibody (CBFYH-0226) (CBMAB-H1097-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0226
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
galanin prepropeptide
Introduction
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system.
Entrez Gene ID
51083
UniProt ID
P22466
Alternative Names
Galanin And GMAP Prepropeptide; Galanin-Message-Associated Peptide; GALN; GLNN; Galanin/GMAP Prepropeptide; Galanin-Related Peptide; Galanin Prepropeptide
Function
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Biological Process
cAMP-mediated signaling Source: UniProtKB
Feeding behavior Source: Ensembl
Inflammatory response Source: Ensembl
Insulin secretion Source: UniProtKB
Negative regulation of lymphocyte proliferation Source: Ensembl
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cortisol secretion Source: UniProtKB
Positive regulation of large conductance calcium-activated potassium channel activity Source: UniProtKB
Positive regulation of timing of catagen Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Protein kinase A signaling Source: UniProtKB
Regulation of glucocorticoid metabolic process Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to insulin Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Epilepsy, familial temporal lobe, 8 (ETL8):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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