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Rabbit Anti-GADD45B Recombinant Antibody (CBLG1-2528) (CBMAB-G1777-LY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLG1-2528
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GROWTH ARREST AND DNA DAMAGE INDUCIBLE BETA
Introduction
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4616
Mouse17873
Rat299626
UniProt ID
HumanO75293
MouseP22339
RatQ5U3Z2
Function
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Biological Process
Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Negative regulation of protein kinase activity Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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