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Rabbit Anti-GABRB2 Recombinant Antibody (BA0086) (CBMAB-0325CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0086
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from residues in Human GABA A Receptor beta 2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
gamma-aminobutyric acid type A receptor beta 2 subunit
Introduction
Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system. GABRB2 is a member of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels through which GABA, the major inhibitory neurotransmitter in the mammalian brain, acts. GABA-A receptors are the site of action of a number of important pharmacologic agents including barbiturates, benzodiazepines, and ethanol. Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Entrez Gene ID
Human2561
Mouse14401
Rat25451
UniProt ID
HumanP47870
MouseP63137
RatP63138
Alternative Names
Gamma-Aminobutyric Acid Type A Receptor Beta2 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Beta 2; GABA(A) Receptor Subunit Beta-2; GABA(A) Receptor; Beta 2
Function
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725).

Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750).

The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).

The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750).

Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
Biological Process
Cellular response to histamine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Cochlea development Source: Ensembl
Gamma-aminobutyric acid signaling pathway Source: UniProtKB
Inhibitory synapse assembly Source: UniProtKB
Inner ear receptor cell development Source: Ensembl
Innervation Source: Ensembl
Ion transmembrane transport Source: GO_Central
Negative regulation of neuron apoptotic process Source: Ensembl
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Sensory perception of sound Source: Ensembl
Signal transduction Source: GO_Central
Synaptic transmission, GABAergic Source: BHF-UCL
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasmic vesicle membrane
Involvement in disease
Epileptic encephalopathy, infantile or early childhood, 2 (IECEE2):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE2 is an autosomal dominant condition with variable age at seizure onset, ranging from early infancy to 6 years.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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