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Rat Anti-FSTL1 Recombinant Antibody (CBXF-2678) (CBMAB-F3085-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse, Rat
Clone
CBXF-2678
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
NS0-derived recombinant mouse Follistatin-like 1/FSTL1, Glu19-Ile306, Accession # NP_032073
Specificity
Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Follistatin Like 1
Introduction
This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.
Entrez Gene ID
Rat79210
Mouse14314
UniProt ID
RatQ62632
MouseQ62356
Alternative Names
Follistatin Like 1; Follistatin-Like Protein 1; FRP; Follistatin-Related Protein 1; Follistatin-Like 1; MIR198;
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:29212066, PubMed:22265692).

Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity).

Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity).

Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Biological Process
Cell differentiation Source: GO_Central
Endothelial cell differentiation Source: UniProtKB
Endothelial cell migration Source: UniProtKB
Hematopoietic stem cell homeostasis Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Cellular Location
Secreted
More Infomation

Ogiwara, Y., Nakagawa, M., Nakatani, F., Uemura, Y., Zhang, R., & Kudo-Saito, C. (2022). Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma. Cancer Letters, 537, 215690.

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., ... & Lu, L. (2022). FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2. Gut, 71(12), 2539-2550.

Li, X., Fang, Y., Jiang, D., Dong, Y., Liu, Y., Zhang, S., ... & Ning, W. (2021). Targeting FSTL1 for multiple fibrotic and systemic autoimmune diseases. Molecular Therapy, 29(1), 347-364.

Loh, J. J., Li, T. W., Zhou, L., Wong, T. L., Liu, X., Ma, V. W., ... & Ma, S. (2021). FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and StemnessFSTL1 from Activated Fibroblasts on HCC. Cancer research, 81(22), 5692-5705.

Li, W., Alahdal, M., Deng, Z., Liu, J., Zhao, Z., Cheng, X., ... & Zhang, J. (2020). Molecular functions of FSTL1 in the osteoarthritis. International immunopharmacology, 83, 106465.

Nie, E., Miao, F., Jin, X., Wu, W., Zhou, X., Zeng, A., ... & You, Y. (2019). Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. Oncogene, 38(15), 2706-2721.

Li, X., Li, L., Chang, Y., Ning, W., & Liu, X. (2019). Structural and functional study of FK domain of Fstl1. Protein Science, 28(10), 1819-1829.

Gu, C., Wang, X., Long, T., Wang, X., Zhong, Y., Ma, Y., ... & Li, Z. (2018). FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway. Cell death & disease, 9(6), 654.

Kudo-Saito, C., Ishida, A., Shouya, Y., Teramoto, K., Igarashi, T., Kon, R., ... & Toyoura, M. (2018). Blocking the FSTL1-DIP2A axis improves anti-tumor immunity. Cell reports, 24(7), 1790-1801.

Ni, X., Cao, X., Wu, Y., & Wu, J. (2018). FSTL1 suppresses tumor cell proliferation, invasion and survival in non-small cell lung cancer. Oncology Reports, 39(1), 13-20.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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