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Mouse Anti-FOLH1 Recombinant Antibody (YPSMA-1) (CBMAB-P0349-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
YPSMA-1
Antibody Isotype
IgG2b
Application
WB, ELISA, IHC-P, IHC-Fr, FC, ICC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamate carboxypeptidase 2
Introduction
FOLH1 is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.
Entrez Gene ID
2346
UniProt ID
Q04609
Alternative Names
Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII;
Function
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Biological Process
C-terminal protein deglutamylation Source: BHF-UCL
Proteolysis Source: BHF-UCL
Cellular Location
Cell membrane
Isoform PSMA': Cytoplasm
Topology
Cytoplasmic: 1-19
Helical: 20-43
Extracellular: 44-750
PTM
The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.
More Infomation

Sun, D., Zhang, A., Gao, B., Zou, L., Huang, H., Zhao, X., & Xu, D. (2022). Identification of Alternative Splicing-Related Genes CYB561 and FOLH1 in the Tumor-Immune Microenvironment for Endometrial Cancer Based on TCGA Data Analysis. Frontiers in Genetics, 13.

Ramirez‐Fort, M. K., Meier‐Schiesser, B., Lachance, K., Mahase, S. S., Church, C. D., Niaz, M. J., ... & Bander, N. H. (2021). Folate hydrolase‐1 (FOLH1) is a novel target for antibody‐based brachytherapy in Merkel cell carcinoma. Skin health and disease, 1(1), e9.

Zink, C. F., Barker, P. B., Sawa, A., Weinberger, D. R., Wang, M., Quillian, H., ... & Bigos, K. L. (2020). Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition. American Journal of Psychiatry, 177(12), 1129-1139.

Bahler, C. D., Johnson, M. M., Davicioni, E., Zhang, J., Cheng, L., Green, M. A., & Koch, M. O. (2020). Predictors of Prostate-specific Membrane Antigen (PSMA/FOLH1) Expression in a Genomic Database. Urology, 144, 117-122.

Kwan, E. M., To, S. Q., Fettke, H. C., Docanto, M. M., Bukczynska, P., Mant, A. M., ... & Azad, A. (2019). Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC).

Šilhavý, J., Marková, I., Hüttl, M., Malínská, H., Kazdová, L., Liška, F., ... & Oliyarnyk, O. (2018). Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats. Physiological research, 67(4), 657-662.

Paul, S., Sadhukhan, S., Munian, D., Bankura, B., & Das, M. (2018). Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India. Birth Defects Research, 110(14), 1129-1138.

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For research use only. Not intended for any clinical use.

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