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Mouse Anti-FGFR1 (phospho Y653 and Y654) Recombinant Antibody (BA0399) (CBMAB-0293CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
BA0399
Antibody Isotype
IgG2b
Application
WB, IHC-P

Basic Information

Immunogen
Corresponding to residues surrounding Tyr653/654 of Human FGFR1
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, FGFR family members differ from one another in their ligand affinities and tissue distribution. This splice variant, termed FGFR1-prime, is expressed in human lung fibroblasts and several other human cell lines. The 2 classes of sequences for recognition and splicing of pre-mRNA in eukaryotes, GT-AG and AT-AC, are characterized by the nearly invariant dinucleotides present at the extreme 5-prime (donor) and 3-prime (acceptor) ends of the intron.The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. The FGFR1-prime variant bound specifically to acidic FGF but ligand binding caused neither receptor autophosphorylation nor activation of phospholipase C (PLC). The authors suggested that the kinase-deficient variant may have an important role in regulating cellular responses elicited by acidic FGF stimulation.
Entrez Gene ID
2260
UniProt ID
P11362
Alternative Names
Fibroblast Growth Factor Receptor 1; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; EC 2.7.10.1; BFGF-R-1; FGFR-1; N-SAM; BFGFR; FGFBR; FLT-2; HBGFR; FLT2; CEK; FLG; Heparin-Binding Growth Factor Receptor; Hydroxyaryl-Protein Kinase; FMS-Like Tyrosine Kinase 2; Fms-Like Tyrosine Kinase 2; FGFR1/PLAG1 Fusion; Pfeiffer Syndrome; CD331 Antigen; EC 2.7.10; HRTFDS; CD331; ECCL; KAL2; HH2; OGD
More Infomation

Zhu, X., Qiu, C., Wang, Y., Jiang, Y., Chen, Y., Fan, L., ... & Yu, L. (2022). FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings of the National Academy of Sciences, 119(26), e2202631119.

Meric-Bernstam, F., Bahleda, R., Hierro, C., Sanson, M., Bridgewater, J., Arkenau, H. T., ... & Goyal, L. (2022). Futibatinib, an irreversible FGFR1–4 inhibitor, in patients with advanced solid tumors harboring FGF/FGFR aberrations: a phase I dose-expansion study. Cancer discovery, 12(2), 402-415.

Hu, Y., Ai, L. S., & Zhou, L. Q. (2021). Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis. PloS one, 16(5), e0251202.

Pozdnyakova, O., Orazi, A., Kelemen, K., King, R., Reichard, K. K., Craig, F. E., ... & Wang, S. A. (2021). Myeloid/lymphoid neoplasms associated with eosinophilia and rearrangements of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2. American journal of clinical pathology, 155(2), 160-178.

Servetto, A., Kollipara, R., Formisano, L., Lin, C. C., Lee, K. M., Sudhan, D. R., ... & Arteaga, C. L. (2021). Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer. Clinical Cancer Research, 27(15), 4379-4396.

Baruch, A., Wong, C., Chinn, L. W., Vaze, A., Sonoda, J., Gelzleichter, T., ... & Arora, P. S. (2020). Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans. Proceedings of the National Academy of Sciences, 117(46), 28992-29000.

Bahleda, R., Meric-Bernstam, F., Goyal, L., Tran, B., He, Y., Yamamiya, I., ... & Arkenau, H. T. (2020). Phase I, first-in-human study of futibatinib, a highly selective, irreversible FGFR1–4 inhibitor in patients with advanced solid tumors. Annals of Oncology, 31(10), 1405-1412.

Li, J., Liu, H., Srivastava, S. P., Hu, Q., Gao, R., Li, S., ... & Kanasaki, K. (2020). Endothelial FGFR1 (fibroblast growth factor receptor 1) deficiency contributes differential fibrogenic effects in kidney and heart of diabetic mice. Hypertension, 76(6), 1935-1944.

Neocleous, V., Fanis, P., Toumba, M., Tanteles, G. A., Schiza, M., Cinarli, F., ... & Phylactou, L. A. (2020). GnRH deficient patients with congenital hypogonadotropic hypogonadism: novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A genes in a case series and review of the literature. Frontiers in endocrinology, 11, 626.

Ryan, M. R., Sohl, C. D., Luo, B., & Anderson, K. S. (2019). The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMTMechanisms of V561M FGFR1–Driven Drug Resistance. Molecular Cancer Research, 17(2), 532-543.

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For research use only. Not intended for any clinical use.

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