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Mouse Anti-FGF13 Recombinant Antibody (CBXF-2971) (CBMAB-F3677-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2971
Antibody Isotype
IgG
Application
ELISA, ICC, IHC, WB

Basic Information

Immunogen
Recombinant FGF13 (Gly108-Arg227) expressed in E. coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 13
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.
Entrez Gene ID
2258
UniProt ID
Q92913
Alternative Names
Fibroblast Growth Factor 13; Fibroblast Growth Factor Homologous Factor 2; FGF-13; FHF-2; FHF2; FGF2;
Research Area
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity).

Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity).

Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity).

May regulate voltage-gated sodium channels transport and function (PubMed:15282281).

May also play a role in MAPK signaling (By similarity).

Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).
Biological Process
Cell-cell signaling Source: ProtInc
Cerebral cortex cell migration Source: UniProtKB
Establishment of neuroblast polarity Source: UniProtKB
Hippocampus development Source: UniProtKB
Inhibitory synapse assembly Source: UniProtKB
Learning Source: UniProtKB
MAPK cascade Source: MGI
Memory Source: UniProtKB
Microtubule polymerization Source: UniProtKB
Negative regulation of collateral sprouting Source: UniProtKB
Negative regulation of microtubule depolymerization Source: UniProtKB
Nervous system development Source: ProtInc
Neuron migration Source: UniProtKB
Protein localization to plasma membrane Source: UniProtKB
Regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
Regulation of voltage-gated sodium channel activity Source: GO_Central
Response to odorant Source: Ensembl
Signal transduction Source: ProtInc
Sodium ion transport Source: BHF-UCL
Cellular Location
Nucleus; Cytoplasm; Filopodium; Growth cone; Dendrite. Not secreted.
Isoform 1: Nucleolus
Isoform 2: Nucleus; Cytoplasm
PTM
May be phosphorylated.
More Infomation

Li, R. M., Xiao, L., Zhang, T., Ren, D., & Zhu, H. (2023). Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage. Neural Regeneration Research, 18(6), 1347-1353.

Shen, K. F., Yue, J., Wu, Z. F., Wu, K. F., Zhu, G., Yang, X. L., ... & Zhang, C. Q. (2022). Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy. Cerebral Cortex.

Li, R., Tao, X., Huang, M., Peng, Y., Liang, J., Wu, Y., & Jiang, Y. (2021). Fibroblast growth factor 13 facilitates peripheral nerve regeneration through maintaining microtubule stability. Oxidative medicine and cellular longevity, 2021.

Wang, Q., Yang, J., Wang, H., Shan, B., Yin, C., Yu, H., ... & Wang, C. (2021). Fibroblast growth factor 13 stabilizes microtubules to promote Na+ channel function in nociceptive DRG neurons and modulates inflammatory pain. Journal of advanced research, 31, 97-111.

Wu, K., Yue, J., Shen, K., He, J., Zhu, G., Liu, S., ... & Yang, H. (2021). Increased expression of fibroblast growth factor 13 in cortical lesions of the focal cortical dysplasia. Brain Research Bulletin, 168, 36-44.

Effraim, P. R., Huang, J., Lampert, A., Stamboulian, S., Zhao, P., Black, J. A., ... & Waxman, S. G. (2019). Fibroblast growth factor homologous factor 2 (FGF-13) associates with Nav1. 7 in DRG neurons and alters its current properties in an isoform-dependent manner. Neurobiology of Pain, 6, 100029.

Lin, H., Lu, P., Zhou, M., Wu, F., Weng, L., Meng, K., ... & Tian, H. (2019). Purification of recombinant human fibroblast growth factor 13 in E. coli and its molecular mechanism of mitogenesis. Applied microbiology and biotechnology, 103(17), 7017-7027.

Liu, Y., Li, S., Tao, T., Li, X., Zhu, Q., Liao, Y., ... & Liu, W. (2018). Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence. Journal of ovarian research, 11(1), 1-6.

Costa, I. B., Teixeira, N. A., Ripamonte, P., Guerra, D. M., Price, C., & Buratini Jr, J. (2018). Expression of fibroblast growth factor 13 (Fgf13) mRNA in bovine antral follicles and corpora lutea. Animal Reproduction (AR), 6(2), 409-415.

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For research use only. Not intended for any clinical use.

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