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Mouse Anti-FAT1 Recombinant Antibody (Fat-1) (CBMAB-F2608-CQ)


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Summary

Host Animal
Mouse
Specificity
Fruit fly
Clone
Fat-1
Antibody Isotype
IgM
Application
WB, ELISA, IF

Basic Information

Specificity
Fruit fly
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FAT Atypical Cadherin 1
Introduction
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
UniProt ID
W8BT52
Alternative Names
FAT Atypical Cadherin 1; Cadherin-Related Tumor Suppressor Homolog; Cadherin-Related Family Member 8; Cadherin Family Member 7; Protein Fat Homolog; CDHF7; FAT; FAT Tumor Suppressor Homolog 1 (Drosophila);
Research Area
Protocadherin Fat 1:
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Biological Process
Actin filament organization Source: UniProtKB
Anatomical structure morphogenesis Source: ProtInc
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cell migration Source: UniProtKB
Epithelial cell morphogenesis Source: Ensembl
Establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis Source: Ensembl
Establishment or maintenance of cell polarity Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Lens development in camera-type eye Source: Ensembl
Cellular Location
Protocadherin Fat 1: Cell membrane
Protocadherin Fat 1, nuclear form: Nucleus
Topology
Extracellular: 22-4181
Helical: 4182-4202
Cytoplasmic: 4203-4588
PTM
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
More Infomation

Chen, Z. G., Saba, N. F., & Teng, Y. (2022). The diverse functions of FAT1 in cancer progression: good, bad, or ugly?. Journal of Experimental & Clinical Cancer Research, 41(1), 1-11.

Irshad, K., Srivastava, C., Malik, N., Arora, M., Gupta, Y., Goswami, S., ... & Chosdol, K. (2022). Upregulation of Atypical Cadherin FAT1 Promotes an Immunosuppressive Tumor Microenvironment via TGF-β. Frontiers in immunology, 13, 813888.

Zhang, W., Tang, Y., Guo, Y., Kong, Y., Shi, F., Sheng, C., ... & Wang, Q. (2022). Favorable immune checkpoint inhibitor outcome of patients with melanoma and NSCLC harboring FAT1 mutations. NPJ precision oncology, 6(1), 1-10.

Peng, Z., Gong, Y., & Liang, X. (2021). Role of FAT1 in health and disease. Oncology Letters, 21(5), 1-13.

Frei, J. A., Brandenburg, C., Nestor, J. E., Hodzic, D. M., Plachez, C., McNeill, H., ... & Lin, Y. C. (2021). Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism. Biology open, 10(6), bio056457.

Wang, F., Liu, P., An, H., & Zhang, Y. (2020). Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1. International journal of molecular medicine, 46(3), 1085-1095.

Hsu, T. N., Huang, C. M., Huang, C. S., Huang, M. S., Yeh, C. T., Chao, T. Y., & Bamodu, O. A. (2019). Targeting FAT1 inhibits carcinogenesis, induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma. Cancers, 11(12), 1883.

Wang, Y., Wang, G., Ma, Y., Teng, J., Wang, Y., Cui, Y., ... & Liu, X. (2019). FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Chinese Journal of Cancer Research, 31(4), 609.

Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J., ... & Cheng, X. (2018). FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncology Reports, 39(5), 2136-2146.

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For research use only. Not intended for any clinical use.

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