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Mouse Anti-FAF1 Recombinant Antibody (CBXF-2499) (CBMAB-F0708-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2499
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Recombinant protein fragment corresponding to amino acids 415-650 of human FAF1 (NP_008982)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fas Associated Factor 1
Introduction
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.
Entrez Gene ID
11124
UniProt ID
Q9UNN5
Alternative Names
Fas Associated Factor 1; Fas (TNFRSF6) Associated Factor 1; UBX Domain-Containing Protein 12; UBX Domain-Containing Protein 3A; TNFRSF6-Associated Factor 1; UBX Domain Protein 3A; UBXD12;
Research Area
Ubiquitin-binding protein (PubMed:19722279).

Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564).

Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytoplasmic sequestering of NF-kappaB Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cell death Source: CACAO
Positive regulation of cellular protein catabolic process Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Positive regulation of protein-containing complex assembly Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of cell adhesion Source: Ensembl
Regulation of protein catabolic process Source: UniProtKB
Cellular Location
Nucleus
More Infomation

Song, S., Park, J. K., Shin, S. C., Lee, J. J., Hong, S. K., Song, I. K., ... & Kim, E. E. (2022). The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation. Journal of Molecular Cell Biology.

Sun, B., Zhou, J., Gao, Y., He, F., Xu, H., Chen, X., ... & Chen, L. (2021). Fas-associated factor 1 promotes hepatic insulin resistance via JNK signaling pathway. Oxidative medicine and cellular longevity, 2021.

Kim, B. S., Jang, T., Yoo, S. E., Lee, J. M., & Kim, E. (2021). Fas‐associated factor 1 induces the accumulation of α‐synuclein through autophagic suppression in dopaminergic neurons. The FASEB Journal, 35(4), e21363.

Park, H. S., Song, Y. S., Moon, B. S., Yoo, S. E., Lee, J. M., Chung, Y. T., ... & Kim, S. E. (2020). Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F] FE-PE2I Positron Emission Tomography Analysis Study. Frontiers in Pharmacology, 11, 953.

Wang, W., Shi, Q., Wang, S., Zhang, H., & Xu, S. (2020). Ammonia regulates chicken tracheal cell necroptosis via the LncRNA-107053293/MiR-148a-3p/FAF1 axis. Journal of hazardous materials, 386, 121626.

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., ... & Lin, D. Y. (2019). Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(8), 1282-1297.

Kim, T. H., Lee, H. C., Kim, J. H., Hewawaduge, C. Y., Chathuranga, K., Chathuranga, W. G., ... & Lee, J. S. (2019). Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection. PLoS Pathogens, 15(8), e1008004.

Lin, D. Y. (2018). Fas‐associated factor 1 (FAF1) binds to mineralocorticoid Receptor (MR) through its SUMO‐interacting motifs and negatively modulates MR transcriptional activity. The FASEB Journal, 32, 791-8.

Peng, H., Huo, J., Gao, Y., Chen, J., Yu, X., & Xiao, T. (2018). Fas-associated protein factor 1 is involved in meiotic resumption in mouse oocytes. Journal of Reproduction and Development, 2017-081.

Kim, J. H., Park, M. E., Nikapitiya, C., Kim, T. H., Uddin, M. B., Lee, H. C., ... & Lee, J. S. (2018). Correction: FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1. PLoS Pathogens, 14(9), e1007302.

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For research use only. Not intended for any clinical use.

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