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Mouse Anti-ESRRA (AA 2-116) Recombinant Antibody (CBFYE-1299) (CBMAB-E1898-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1299
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
Recombinant corresponding to aa2-116 from human ERa expressed in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-116

Target

Full Name
Estrogen Related Receptor Alpha
Introduction
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
2101
UniProt ID
P11474
Alternative Names
Estrogen Related Receptor Alpha; Nuclear Receptor Subfamily 3 Group B Member 1; Estrogen Receptor-Like 1; ERR-Alpha; ESRL1; NR3B1; ERR1
Research Area
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Biological Process
Cartilage development Source: Ensembl
Positive regulation of cellular response to insulin stimulus Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of cell population proliferation Source: Ensembl
Regulation of ossification Source: Ensembl
Regulation of osteoblast differentiation Source: Ensembl
Regulation of osteoclast differentiation Source: Ensembl
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Co-localizes to the cytoplasm only in presence of MAPK15.
PTM
Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
More Infomation

Li, F. N., Zhang, Q. Y., Li, O., Liu, S. L., Yang, Z. Y., Pan, L. J., ... & Dong, P. (2021). ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1. International journal of biological sciences, 17(8), 1909.

Bergeron, A., MacGrogan, G., Bertaut, A., Ladoire, S., Arveux, P., Desmoulins, I., ... & Arnould, L. (2021). Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations. Modern Pathology, 34(7), 1282-1296.

Dhillon, P., Park, J., Del Pozo, C. H., Li, L., Doke, T., Huang, S., ... & Susztak, K. (2021). The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation. Cell metabolism, 33(2), 379-394.

Kim, S., Lee, J. Y., Shin, S. G., Kim, J. K., Silwal, P., Kim, Y. J., ... & Jo, E. K. (2021). ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Autophagy, 17(10), 2856-2875.

Ismael, W. M., Gao, M., & Yemeni, Z. (2021). ESRRA-IoT: Edge-based spatial redundancy reduction approach for Internet of Things. Internet of Things, 14, 100388.

Kan, J., Hu, Y., Ge, Y., Zhang, W., Lu, S., Zhao, C., ... & Liu, Y. (2021). Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging. Bioengineered, 12(1), 3485-3502.

Wang, S., & Huo, X. (2021). Comprehensive analysis of ESRRA in endometrial cancer. Technology in Cancer Research & Treatment, 20, 1533033821992083.

Huang, X. (2020). 387 Estrogen-related receptor alpha (ESRRA) copy number variation is associated with histological grade in ovarian cancer. International Journal of Gynecological Cancer, 30(Suppl 3), A161-A161.

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For research use only. Not intended for any clinical use.

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