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Mouse Anti-ERC1 Monoclonal Antibody (ELKS-30) (CBMAB-1190-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Chicken, Cattle
Clone
ELKS-30
Antibody Isotype
IgG2a
Application
ELISA, ICC, IF, IP, WB

Basic Information

Immunogen
Synthetic peptide: SPRLPRSPRLGHRRTNSTGG, corresponding to amino acids 21 - 40 of Human ERC1.
Specificity
Human, Mouse, Rat, Chicken, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELKS/RAB6-Interacting/CAST Family Member 1
Introduction
ERC1 is a member of a family of RIM-binding proteins. ERC1 has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma.
Entrez Gene ID
Human23085
Mouse111173
Rat266806
Cattle519271
Chicken418153
UniProt ID
HumanQ8IUD2
MouseQ99MI1
RatQ811U3
CattleE1BPW2
ChickenE1BQR7
Alternative Names
ELKS; Cast2; ERC-1; RAB6IP2
Research Area
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
Biological Process
I-kappaB phosphorylation Source: UniProtKB
Maintenance of presynaptic active zone structure Source: GO_Central
Multicellular organism development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neuromuscular synaptic transmission Source: GO_Central
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of synaptic plasticity Source: GO_Central
Regulation of transcription, DNA-templated Source: UniProtKB
Retrograde transport, endosome to Golgi Source: ParkinsonsUK-UCL
Cellular Location
Golgi apparatus membrane; Centrosome; Presynaptic cell membrane; Cytoplasm; Membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity).
Involvement in disease
A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity.
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For research use only. Not intended for any clinical use.

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