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Mouse Anti-EFHD1 (AA 168-238) Recombinant Antibody (CBFYE-0477) (CBMAB-E0824-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0477
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
EFHD1 full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: GLMALAKLSE IDVALEGVKG AKNFFEAKVQ ALSSASKFEA ELKAEQDERK REEEERRLRQ AAFQKLKANF N
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 168-238

Target

Full Name
EF-Hand Domain Family Member D1
Introduction
This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
80303
UniProt ID
Q9BUP0
Alternative Names
EF-Hand Domain Family Member D1; Swiprosin-2; EF-Hand Domain-Containing Protein 1; SWS2; EF-Hand Domain-Containing Protein D1; EF Hand Domain Containing 1; MSTP133; MST133; PP3051;
Research Area
Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899).

May play a role in neuronal differentiation (By similarity).
Biological Process
Neuron projection development Source: Ensembl
Regulation of cellular hyperosmotic salinity response Source: UniProtKB
Cellular Location
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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