Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0036) (V2LY-0425-LY1491)

Name: Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0036)
SKU: V2LY-0425-LY1491
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBFYE-0036

Antibody Isotype

IgG1

Application

WB, IF, IHC

Basic Information

Immunogen

Synthetic Peptide of EFHD1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:2,000
IF(ICC)	1:100-1:200
IHC	1:50-1:300

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

EF-Hand Domain Family Member D1

Entrez Gene ID

Human	80303
Mouse	98363
Rat	501181

UniProt ID

Human	Q9BUP0
Mouse	Q9D4J1
Rat	D4A9T5

Alternative Names

EF-Hand Domain Family Member D1; Swiprosin-2; EF-Hand Domain-Containing Protein 1; SWS2; EF-Hand Domain-Containing Protein D1; EF Hand Domain Containing 1; MSTP133; MST133; PP3051;

Research Area

Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899).

May play a role in neuronal differentiation (By similarity).

Biological Process

Neuron projection development Source: Ensembl
Regulation of cellular hyperosmotic salinity response Source: UniProtKB

Cellular Location

Mitochondrion inner membrane

More Infomation

References

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E. C., Kraiss, J. N., ... & Chaudhuri, D. (2022). EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia. Journal of Molecular and Cellular Cardiology, 167, 1-14.

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E., Kraiss, J. N., ... & Chaudhuri, D. (2021). EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia. bioRxiv.

Eberhardt, D. R., Yin, X., Balynas, A., Lee, S., Walsh, M., Funai, K., & Chaudhuri, D. (2021, September). Abstract P339: Examining Cardiac Phenotypes Of EF Hand Containing Domain 1 Protein (EFHD1) Knockout Mice. In Circulation Research (Vol. 129, No. Suppl_1, pp. AP339-AP339). Hagerstown, MD: Lippincott Williams & Wilkins.

Mun, S. A., Park, J., Park, K. R., Lee, Y., Kang, J. Y., Park, T., ... & Eom, S. H. (2021). Structural and biochemical characterization of EFhd1/Swiprosin-2, an actin-binding protein in mitochondria. Frontiers in cell and developmental biology, 8, 628222.

Ulisse, V., Dey, S., Rothbard, D. E., Zeevi, E., Gokhman, I., Dadosh, T., ... & Yaron, A. (2020). Regulation of axonal morphogenesis by the mitochondrial protein Efhd1. Life science alliance, 3(7).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-EFHD1 (AA 168-238) Recombinant Antibody (CBFYE-0036)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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