Mouse Anti-EDDM3A (AA 1-147 ) Recombinant Antibody (CBFYE-0434) (CBMAB-E0754-FY)

Name: Mouse Anti-EDDM3A (AA 1-147 ) Recombinant Antibody (CBFYE-0434)
SKU: CBMAB-E0754-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0434

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

FAM12A full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MTSSLKIWGI LLALLCILCR LCVYSNNIYW REFIKLHYLS PSREFKEYKC DVLMREKEAL KGKSFHMFIY SLWFKIQRAC INEKGSDRYR NAYVWAPGAL KVLECHWEKY NNRYTESRSF SYIEFHCGVD GYVDNIEDLR IIEPISN

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-147

Target

Full Name

Epididymal Protein 3A

Introduction

Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells.

Entrez Gene ID

10876

UniProt ID

Q14507

Alternative Names

Epididymal Protein 3A; Family With Sequence Similarity 12, Member A; Human Epididymis-Specific Protein 3-Alpha; HE3-ALPHA; FAM12A; HE3A; Epididymal Secretory Protein E3-Alpha

Research Area

Possible function in sperm maturation.

Biological Process

Sperm displacement Source: ProtInc

Cellular Location

Secreted

More Infomation

References

Wu, T., Yang, Y., Zhang, B., Zhang, Z. S., Zhou, S., Jia, G. Z., ... & Wang, N. (2022). EDDM3A drives gastric cancer progression by promoting HIF-1α-dependent aerobic glycolysis. Oncogenesis, 11(1), 1-11.

Li, G., Tong, X., Pan, L., Huang, H., Ma, H., & Feng, Y. (2020). Epididymal protein 3A is upregulated and promotes cell proliferation in non‑small cell lung cancer. Oncology Letters, 19(6), 4024-4030.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EDDM3A Recombinant Antibody (3D9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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