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Mouse Anti-EDA2R Recombinant Antibody (5D7E3) (CBMAB-X0012-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5D7E3
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant human XEDAR/EDA2R protein.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EDA2R
Introduction
EDA2R is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. EDA2R binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. EDA2R mediates the activation of the NF-kappa-B and JNK pathways and activation seems to be mediated by binding to TRAF3 and TRAF6.
Entrez Gene ID
60401
UniProt ID
Q9HAV5
Alternative Names
XEDAR; EDAA2R; EDA-A2R; TNFRSF27
Research Area
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Biological Process
Ectodermal cell differentiation Source: BHF-UCL
Epidermis development Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: HGNC-UCL
Positive regulation of NF-kappaB transcription factor activity Source: HGNC-UCL
Cellular Location
Membrane
Topology
Extracellular: 1-138
Helical: 139-159
Cytoplasmic: 160-297
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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