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Mouse Anti-DSG3 Recombinant Antibody (5G11) (CBMAB-D1781-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5G11
Antibody Isotype
IgG1, κ
Application
WB, IHC-P, ICC, IF, FC

Basic Information

Immunogen
A recombinant human protein corresponding to the extracellular portion of DSG3
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Desmoglein 3
Introduction
DSG3 belongs to the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
Entrez Gene ID
1830
UniProt ID
P32926
Alternative Names
Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3;
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Biological Process
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Cellular Location
Cell membrane; Desmosome
Topology
Extracellular: 50-615
Helical: 616-640
Cytoplasmic: 641-999
More Infomation

Chi, Z., Balani, J., Gopal, P., Hammer, S., Lewis, C. M., & Peng, L. (2022). Characterization of Desmoglein 3 (DSG3) as a Sensitive and Specific Marker for Esophageal Squamous Cell Carcinoma. Gastroenterology Research and Practice, 2022.

Troeltzsch, M., Künzel, V., Haidari, S., Troeltzsch, M., Otto, S., Ehrenfeld, M., ... & Knösel, T. (2022). Desmoglein-3 overexpression in oral squamous cell carcinoma is associated with metastasis formation and early recurrence: An immunohistochemical study. Journal of Cranio-Maxillofacial Surgery, 50(3), 281-288.

Iriki, H., Takahashi, H., Wada, N., Nomura, H., Mukai, M., Kamata, A., ... & Amagai, M. (2021). Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. Proceedings of the National Academy of Sciences, 118(49).

Rehman, A., Huang, Y., & Wan, H. (2021). Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein. Life, 11(7), 621.

Fuchs, M., Sigmund, A. M., Waschke, J., & Vielmuth, F. (2020). Desmosomal hyperadhesion is accompanied with enhanced binding strength of desmoglein 3 molecules. Biophysical journal, 119(8), 1489-1500.

Rehman, A., Cai, Y., Hünefeld, C., Jedličková, H., Huang, Y., Teck Teh, M., ... & Wan, H. (2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Cell death & disease, 10(10), 1-14.

Ri, H., Peiyan, Z., Jianqi, W., Yunteng, Z., Gang, L., & Baoqing, S. (2019). Desmoglein 3 gene mediates epidermal growth factor/epidermal growth factor receptor signaling pathway involved in inflammatory response and immune function of anaphylactic rhinitis. Biomedicine & Pharmacotherapy, 118, 109214.

Apu, E. H., Akram, S. U., Rissanen, J., Wan, H., & Salo, T. (2018). Desmoglein 3–Influence on oral carcinoma cell migration and invasion. Experimental Cell Research, 370(2), 353-364.

Moftah, H., Dias, K., Apu, E. H., Liu, L., Uttagomol, J., Bergmeier, L., ... & Wan, H. (2017). Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion. Cell adhesion & migration, 11(3), 211-232.

Mao, X., Cho, M. J. T., Ellebrecht, C. T., Mukherjee, E. M., & Payne, A. S. (2017). Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. JCI insight, 2(9).

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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