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Mouse Anti-DSC3 Recombinant Antibody (4D2) (V2LY-0425-LY955)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D2
Antibody Isotype
IgG2b, κ
Application
IF, WB, ELISA

Basic Information

Immunogen
DSC3 (aa585-684) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
desmocollin 3
Entrez Gene ID
1825
UniProt ID
Q14574
Research Area
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Biological Process
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Protein stabilization Source: BHF-UCL
Cellular Location
Cell membrane; Desmosome
Involvement in disease
Hypotrichosis and recurrent skin vesicles (HRSV):
A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the body. Mucosal vesicles are absent.
Topology
Extracellular: 136-690
Helical: 691-711
Cytoplasmic: 712-896
More Infomation

Hudemann, C., Maglie, R., Llamazares-Prada, M., Beckert, B., Didona, D., Tikkanen, R., ... & Eming, R. (2022). Human Desmocollin 3‒Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus. Journal of Investigative Dermatology, 142(3), 915-923.

Meltzanidou, P., Patsatsi, A., Kyriakou, A., Vareli, K., & Lambropoulos, A. (2019). Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus. Acta Dermatovenerologica Croatica, 27(1), 8-8.

Ko, H., Hasegawa, H., Ochiai, T., Shimada, K., Roy, R. R., Aizawa, S., & Yamada, H. (2019). Loss of Basal Cell Character in Regenerating Oral Squamous Epithelium with Altered Expression of Desmoglein 1, Desmocollin 3 and Keratin 19. Journal of Hard Tissue Biology, 28(1), 43-50.

Cui, T., Yang, L., Ma, Y., Petersen, I., & Chen, Y. (2019). Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer. Experimental Cell Research, 378(2), 124-130.

Lotti, R., Atene, C. G., Marconi, A., Di Rocco, G., Reggiani Bonetti, L., Zanocco Marani, T., & Pincelli, C. (2019). Development of a desmocollin-3 active mouse model recapitulating human atypical pemphigus. Frontiers in immunology, 1387.

Iranzo, P., Ishii, N., Hashimoto, T., & Alsina‐Gibert, M. (2019). Nonclassical pemphigus with exclusively IgG anti‐desmocollin 3‐specific antibodies. Australasian Journal of Dermatology, 60(3), e217-e219.

Adaszewska, A., Ishii, N., Dwilewicz-Trojaczek, J., Woźniak, K., Hashimoto, T., & Kowalewski, C. (2018). Paraneoplastic pemphigus with anti-desmocollin 3 autoantibodies and chronic lymphocytic leukemia. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 35(1), 113.

Belani, C. P., Chakraborty, B. C., Modi, R. I., & Khamar, B. M. (2017). A randomized trial of TLR-2 agonist CADI-05 targeting desmocollin-3 for advanced non-small-cell lung cancer. Annals of Oncology, 28(2), 298-304.

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For research use only. Not intended for any clinical use.

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