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Mouse Anti-DPYSL3 Recombinant Antibody (9G340) (CBMAB-D1657-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9G340
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein of human DRP-3 (a.a.457 to 556) with a GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dihydropyrimidinase-like 3
Introduction
DPYSL3 (Dihydropyrimidinase Like 3) is a protein coding gene.Diseases associated with DPYSL3 include Prostate Lymphoma and Hypertensive Encephalopathy. Among its related pathways are Semaphorin interactions and Developmental Biology. It has proved that the protein has hydrolase activity and phosphoprotein binding. And a paralog is CRMP1.
Entrez Gene ID
1809
UniProt ID
Q14195
Alternative Names
Dihydropyrimidinase Like 3; Unc-33-Like Phosphoprotein 1; CRMP-4; ULIP-1; CRMP4; DRP-3; DRP3; ULIP;
Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Biological Process
Actin crosslink formation Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of neuron projection development Source: UniProtKB
Neuron development Source: Ensembl
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of neuron projection development Source: UniProtKB
Response to axon injury Source: UniProtKB
Cellular Location
Cytoplasm; Growth cone. Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
PTM
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
More Infomation

Zhong, H., & Luo, X. (2021). Serum Dihydropyrimidinase-Like 3 Concentration in Patients with Gastric Cancer and Its Diagnostic Value. Iranian Journal of Public Health, 50(9), 1789.

Tsai, Y. M., Wu, K. L., Chang, Y. Y., Hung, J. Y., Chang, W. A., Chang, C. Y., ... & Hsu, Y. L. (2020). Upregulation of Thr/Tyr kinase increases the cancer progression by neurotensin and dihydropyrimidinase-Like 3 in lung cancer. International Journal of Molecular Sciences, 21(5), 1640.

Umetsu, S., Mizukami, H., Saito, T., Uchida, C., Igawa, A., Kudo, K., ... & Hakamada, K. (2020). Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation. Scientific reports, 10(1), 1-11.

Mamoor, S. (2020). Dihydropyrimidinase like 3 (DPYSL3) is differentially expressed in metastatic breast cancer, both in metastases to the brain and to the lymph nodes.

Matsunuma, R., Chan, D. W., Kim, B. J., Singh, P., Han, A., Saltzman, A., ... & Ellis, M. J. (2019). Abstract P5-08-01: DPYSL3 modulates mitosis, migration and epithelial to mesenchymal transition in claudin-low breast cancer.

Matsunuma, R., Chan, D. W., Kim, B. J., Singh, P., Han, A., Saltzman, A. B., ... & Ellis, M. J. (2018). DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Proceedings of the National Academy of Sciences, 115(51), E11978-E11987.

Yang, Y., Jiang, Y., Xie, D., Liu, M., Song, N., Zhu, J., ... & Zhu, C. (2018). Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer. Respiratory research, 19(1), 1-7.

Matsunuma, R., Chan, D. W., Kim, B. J., Singh, P., Han, A., Malovannaya, A., ... & Ellis, M. J. (2018). Abstract P1-01-08: DPYSL3 modulates proliferation and migration in claudin-low breast cancer.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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