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Mouse Anti-DNAI1 Recombinant Antibody (CBYCD-329) (V2LY-0425-LY603)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYCD-329
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Synthetic peptide amino acids 22-41 of human DNAIC1.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tris
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dynein Axonemal Intermediate Chain 1
Entrez Gene ID
Human27019
Mouse68922
UniProt ID
HumanQ9UI46
MouseQ8C0M8
Function
Part of the dynein complex of respiratory cilia.
Biological Process
Cilium movement Source: SYSCILIA_CCNET
Determination of left/right symmetry Source: SYSCILIA_CCNET
Epithelial cilium movement involved in extracellular fluid movement Source: Ensembl
Flagellated sperm motility Source: SYSCILIA_CCNET
Heart development Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Microtubule-based movement Source: GO_Central
Outer dynein arm assembly Source: SYSCILIA_CCNET
Cellular Location
Cilium axoneme; Dynein axonemal particle
Involvement in disease
Ciliary dyskinesia, primary, 1 (CILD1):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Kartagener syndrome (KTGS):
An autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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