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Armenian Hamster Anti-DLL1 Recombinant Antibody (HMD1-5) (CBMAB-1012-LY)


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Summary

Host Animal
Armenian Hamster
Specificity
Mouse
Clone
HMD1-5
Antibody Isotype
IgG
Application
Neutralization, FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD)
Entrez Gene ID
13388
UniProt ID
Q61483
Alternative Names
Delta1
More Infomation

Hildebrand, D., Nurjadi, D., Hoan, N. X., Linh, M. T. H., Sang, V. V., Bang, M. H., ... & Velavan, T. P. (2022). Association Between Soluble Notch Ligand Delta-like Ligand 1 and Bleeding Complications in Patients With Dengue Fever Infection. The Journal of Infectious Diseases, 225(3), 476-480.

Pittaway, J. F., Lipsos, C., Mariniello, K., & Guasti, L. (2021). The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer. Endocrine-related cancer, 28(12), R271-R287.

Decker, S. O., Hildebrand, D., Bruckner, T., Lichtenstern, C., Heeg, K., Weigand, M. A., ... & Uhle, F. (2020). Delta-Like Canonical Notch Ligand 1 in Patients Following Liver Transplantation—A Secondary Analysis of a Prospective Cohort Study. Diagnostics, 10(11), 894.

Hildebrand, D., Decker, S. O., Koch, C., Schmitt, F. C., Ruhrmann, S., Schneck, E., ... & Uhle, F. (2019). Host-Derived Delta-Like Canonical Notch Ligand 1 as a Novel Diagnostic Biomarker for Bacterial Sepsis—Results From a Combinational Secondary Analysis. Frontiers in cellular and infection microbiology, 267.

Norum, H. M., Michelsen, A. E., Lekva, T., Arora, S., Otterdal, K., Olsen, M. B., ... & Ueland, T. (2019). Circulating delta‐like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus‐based immunosuppression. American Journal of Transplantation, 19(4), 1050-1060.

Radojcic, V., Paz, K., Chung, J., Du, J., Perkey, E. T., Flynn, R., ... & Maillard, I. (2018). Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice. Blood, The Journal of the American Society of Hematology, 132(20), 2188-2200.

Norum, H. M., Broch, K., Michelsen, A. E., Lunde, I. G., Lekva, T., Abraityte, A., ... & Ueland, T. (2017). The notch ligands DLL1 and periostin are associated with symptom severity and diastolic function in dilated cardiomyopathy. Journal of Cardiovascular Translational Research, 10(4), 401-410.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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