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Rabbit Anti-DLG4 (phospho S418) Recombinant Antibody (BA0213) (CBMAB-0262CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0213
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic phospho-peptide from residues surrounding serine 418 of human PSD95
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The predicted 723-amino acid DLG4 protein has 3 PSD95-DLG-Z01 (PDZ) domains in its N-terminal half, a central src homology-3 (SH3) motif, and a C-terminal guanylate kinmologous domain. The human DLG4 protein is 99% identical to the rat and mouse Psd95 proteins and 56% identical to the Drosophila Dlg protein. Northern blot analysis detected 6 DLG4 transcripts with different expression patterns, including a 4.2-kb transcript that was variably expressed in all 17 human tissues examined. Western blot analysis using antibodies against DLG4 detected multiple proteins with complex distribution patterns, including a ubiquitous 85-kD and tissue-specific variants. DLG4 gene contains 22 exons and spans about 30 kb. All splice sites conform to the GT-AG rule, except for the splice acceptor site of intron 5, which is TG instead of AG. The promoter region contains no TATA or CAAT boxes, but has a large GC-rich domain with characteristics of a CpG island. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human1742
Mouse13385
Rat29495
UniProt ID
HumanP78352
MouseQ62108
RatP31016
Alternative Names
Discs, Large Homolog 4 (Drosophila); Postsynaptic Density Protein 95; Synapse-Associated Protein 90; SAP-90; PSD95; SAP90; Post-Synaptic Density Protein 95; Tax Interaction Protein 15; Discs Large Homolog 4; PSD-95
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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