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Rabbit Anti-DCLK1 Monoclonal Antibody (0987) (V2LY-0125-LY1194)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
0987
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Synthetic peptide within Human DCAMKL1 aa 649-698.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:1,000
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA, Glycerol & TBS
Preservative
Sodium Azide
Concentration
1 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Doublecortin Like Kinase 1
Entrez Gene ID
Human9201
Mouse13175
Rat83825
UniProt ID
HumanO15075
MouseQ9JLM8
RatO08875
Function
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Biological Process
Axon extension Source: Ensembl
Central nervous system development Source: ProtInc
Central nervous system projection neuron axonogenesis Source: Ensembl
Dendrite morphogenesis Source: Ensembl
Endosomal transport Source: UniProtKB
Forebrain development Source: Ensembl
Intracellular signal transduction Source: InterPro
Negative regulation of protein localization to nucleus Source: Ensembl
Nervous system development Source: ProtInc
Neuron migration Source: Ensembl
Neuron projection morphogenesis Source: GO_Central
Peptidyl-serine phosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Response to virus Source: UniProtKB
Cellular Location
Integral component of plasma membrane; Postsynaptic density
More Infomation

Patel, O., Roy, M. J., Kropp, A., Hardy, J. M., Dai, W., & Lucet, I. S. (2021). Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Communications biology, 4(1), 1-13.

Agulto, R. L., Rogers, M. M., Tan, T. C., Ramkumar, A., Downing, A. M., Bodin, H., ... & Ori-McKenney, K. M. (2021). Autoregulatory control of microtubule binding in doublecortin-like kinase 1. Elife, 10, e60126.

Onisha, P., Roy, M. J., Ashleigh, K., Hardy, J. M., Weiwen, D., & Lucet, I. S. (2021). Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Communications Biology, 4(1).

Ferguson, F. M., Nabet, B., Raghavan, S., Liu, Y., Leggett, A. L., Kuljanin, M., ... & Gray, N. S. (2020). Discovery of a selective inhibitor of doublecortin like kinase 1. Nature chemical biology, 16(6), 635-643.

Vázquez-Vélez, G. E., Gonzales, K. A., Revelli, J. P., Adamski, C. J., Naini, F. A., Bajić, A., ... & Zoghbi, H. Y. (2020). Doublecortin-like kinase 1 regulates α-synuclein levels and toxicity. Journal of Neuroscience, 40(2), 459-477.

Wang, J., Wang, S., Zhou, J., & Qian, Q. (2018). miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer. Biomedicine & Pharmacotherapy, 102, 147-152.

Li, J., Wang, Y., Ge, J., Li, W., Yin, L., Zhao, Z., ... & Wang, H. (2018). Doublecortin-like kinase 1 (DCLK1) regulates B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) and is associated with metastasis and prognosis in pancreatic cancer. Cellular Physiology and Biochemistry, 51(1), 262-277.

Fan, M., Qian, N., & Dai, G. (2017). Expression and prognostic significance of doublecortin‑like kinase 1 in patients with hepatocellular carcinoma. Oncology Letters, 14(6), 7529-7537.

Westphalen, C. B., Quante, M., & Wang, T. C. (2017). Functional implication of Dclk1 and Dclk1-expressing cells in cancer. Small GTPases, 8(3), 164-171.

Wu, X., Ruan, Y., Jiang, H., & Xu, C. (2017). MicroRNA-424 inhibits cell migration, invasion, and epithelial mesenchymal transition by downregulating doublecortin-like kinase 1 in ovarian clear cell carcinoma. The International Journal of Biochemistry & Cell Biology, 85, 66-74.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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