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Recombinant Mouse Anti-DCD Antibody (CBHb139) (V2LY-0125-LY1179)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBHb139
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 72-97 near the C-terminus of human Dermcidin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dermcidin
Entrez Gene ID
117159
UniProt ID
P81605
Function
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).

Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to bacterium Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Killing by host of symbiont cells Source: CACAO
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted
More Infomation

Farshadzadeh, Z., Pourhajibagher, M., Taheri, B., Ekrami, A., Modarressi, M. H., Azimzadeh, M., & Bahador, A. (2022). Antimicrobial and anti-biofilm potencies of dermcidin-derived peptide DCD-1L against Acinetobacter baumannii: an in vivo wound healing model. BMC microbiology, 22(1), 1-13.

Qiu, F., Long, H., Zhang, L., Liu, J., Yang, Z., & Huang, X. (2022). Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo. Journal of Clinical and Translational Hepatology, (000), 0-0.

Lager, T. W., Conner, C., Keating, C. R., Warshaw, J. N., & Panopoulos, A. D. (2021). Cell surface Grp78 and dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling. Oncogene, 40(23), 4050-4059.

Alatas, E. T., Kara Polat, A., Kalayci, M., Dogan, G., & Akin Belli, A. (2019). Plasma dermcidin levels in acne patients, and the effect of isotretinoin treatment on dermcidin levels. Dermatologic Therapy, 32(5), e13044.

Song, C., de Groot, B. L., & Sansom, M. S. (2019). Lipid bilayer composition influences the activity of the antimicrobial peptide dermcidin channel. Biophysical journal, 116(9), 1658-1666.

Qiu, F., Qiu, F., Liu, L., Liu, J., Xu, J., & Huang, X. (2018). The Role of dermcidin in the diagnosis and staging of hepatocellular carcinoma. Genetic Testing and Molecular Biomarkers, 22(4), 218-223.

Mohanraj, U., Kinnunen, O., Kaya, M. E., Aranko, A. S., Viskari, H., & Linder, M. (2018). SUMO-based expression and purification of dermcidin-derived DCD-1L, a human antimicrobial peptide, in Escherichia coli. BioRxiv, 343418.

Nguyen, V. S., Tan, K. W., Ramesh, K., Chew, F. T., & Mok, Y. K. (2017). Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Scientific reports, 7(1), 1-11.

Zeth, K., & Sancho-Vaello, E. (2017). The human antimicrobial peptides dermcidin and LL-37 show novel distinct pathways in membrane interactions. Frontiers in chemistry, 5, 86.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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