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Mouse Anti-DBNL Recombinant Antibody (CBXS-5808) (V2LY-0125-LY1160)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-5808
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 100-186 mapping near the N-terminus of human HIP-55.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Drebrin Like
Entrez Gene ID
28988
UniProt ID
Q9UJU6
Function
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity).

May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
Biological Process
Activation of JUN kinase activity Source: ProtInc
Adaptive immune response Source: UniProtKB-KW
Neuron projection morphogenesis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Podosome assembly Source: UniProtKB
Positive regulation of axon extension Source: GO_Central
Positive regulation of dendritic spine morphogenesis Source: GO_Central
Postsynaptic actin cytoskeleton organization Source: GO_Central
Rac protein signal transduction Source: UniProtKB
Receptor-mediated endocytosis Source: InterPro
Regulation of actin filament polymerization Source: GO_Central
Ruffle assembly Source: InterPro
Synapse assembly Source: UniProtKB
Cellular Location
Cell membrane; Golgi apparatus membrane; Early endosome; Cytosol; Cytoskeleton; Lamellipodium; Ruffle; Cell cortex; Synapse; Perikaryon; Neuron projection; Clathrin-coated vesicle membrane; Podosome; Dendrite; Postsynaptic density. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes.
PTM
Degraded by caspases during apoptosis.
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For research use only. Not intended for any clinical use.

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