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Mouse Anti-DBF4B Recombinant Antibody (1A7) (V2LY-0125-LY1137)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A7
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
DBF4B (201-299aa) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DBF4 homolog B (S. cerevisiae)
Entrez Gene ID
80174
UniProt ID
Q8NFT6
Function
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.
Biological Process
Cell cycle Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
Positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
Regulation of cell cycle phase transition Source: GO_Central
Cellular Location
Nucleus. Predominantly found in soluble fraction but not in the chromatin-bound fraction.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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