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Rat Anti-CYTIP Recombinant Antibody (PDZ2F9) (CBMAB-0254CQ)


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Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
PDZ2F9
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Fusion protein from Human PSCDBP
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytohesin 1 Interacting Protein
Introduction
The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.This protein is expressed weakly in resting NK and T cells. Using a somatic cell hybrid mapping panel, Kim (1999) mapped the PSCDBP gene to chromosome 2. They localized the PSCDBP gene to 2q11.2 by radiation hybrid mappingThe encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.
Entrez Gene ID
Human9595
Mouse227929
UniProt ID
HumanO60759
MouseQ91VY6
Alternative Names
HE; B3-1; CASP; CYBR; CYTHIP; PSCDBP
Function
By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
Biological Process
Regulation of cell adhesion Source: MGI
Cellular Location
Early endosome; Cytoplasm. Recruited from the cytosol to endosomes by SNX27.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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