Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CXCL17 Recombinant Antibody (CBXC-1181) (CBMAB-C1447-CQ)


See all CXCL17 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1181
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 24-66 mapping within an internal region of human VCC-1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
C-X-C Motif Chemokine Ligand 17
Entrez Gene ID
284340
UniProt ID
Q6UXB2
Function
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Biological Process
Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB
Cellular Location
Secreted
PTM
Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.
More Infomation

Wang, L. P., Lin, J., Ma, X. Q., Xu, D. Y., Shi, C. F., Wang, W., & Jiang, X. J. (2021). Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Choreño-Parra, J. A., Jiménez-Álvarez, L. A., Ramírez-Martínez, G., Sandoval-Vega, M., Salinas-Lara, C., Sánchez-Garibay, C., ... & Zúñiga, J. (2021). CXCL17 is a specific diagnostic biomarker for severe pandemic influenza A (H1N1) that predicts poor clinical outcome. Frontiers in immunology, 12.

Fermin, J. M., Alam, M. M., Gu, X., Asarkar, A., Nathan, C. A., & Khandelwal, A. R. (2021). CXCL17 as a prognostic biomarker for aggressive cutaneous squamous cell carcinoma.

Yao, H., Lv, Y., Bai, X., Yu, Z., & Liu, X. (2020). Prognostic value of CXCL17 and CXCR8 expression in patients with colon cancer. Oncology letters, 20(3), 2711-2720.

Choreño-Parra, J. A., Thirunavukkarasu, S., Zúñiga, J., & Khader, S. A. (2020). The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. Cytokine & growth factor reviews, 53, 53-62.

Liu, W., Xie, X., & Wu, J. (2020). Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17. Cellular Oncology, 43(2), 311-320.

Rojewska, E., Ciapała, K., & Mika, J. (2019). Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacological Reports, 71(1), 139-148.

Khandelwal, A. R., Alam, M. M., Moore-Medlin, T., Savage, H. A., & Nathan, C. A. O. (2019). Role of the CXCL17-CXCR8 (GPR35) axis in cutaneous squamous cell carcinoma.

Zhang, K., Liang, Y., Feng, Y., Wu, W., Zhang, H., He, J., ... & Zhen, G. (2018). Decreased epithelial and sputum miR-221-3p associates with airway eosinophilic inflammation and CXCL17 expression in asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology, 315(2), L253-L264.

Guo, Y. J., Zhou, Y. J., Yang, X. L., Shao, Z. M., & Ou, Z. L. (2017). The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications, 493(3), 1159-1167.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CXCL17 Recombinant Antibody (CBXC-1181)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry