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Rabbit Anti-CXADR Recombinant Antibody (001) (V2LY-0125-LY589)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
001
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human CXADR / CAR protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CXADR, Ig-Like Cell Adhesion Molecule
Entrez Gene ID
1525
UniProt ID
P78310
Function
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

(Microbial infection) Acts as a receptor for adenovirus type C.

(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Biological Process
Actin cytoskeleton reorganization Source: UniProtKB
AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
AV node cell to bundle of His cell communication Source: UniProtKB
Cardiac muscle fiber development Source: UniProtKB
Cell-cell junction organization Source: UniProtKB
Defense response to virus Source: UniProtKB
Epithelial structure maintenance Source: UniProtKB
Gamma-delta T cell activation Source: UniProtKB
Germ cell migration Source: UniProtKB
Heart development Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Mitochondrion organization Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of AV node cell action potential Source: BHF-UCL
Regulation of immune response Source: Reactome
Transepithelial transport Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane; Basolateral cell membrane; Tight junction; Adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).
Isoform 3&4&5: Secreted
Topology
Extracellular: 20-237
Helical: 238-258
Cytoplasmic: 259-365
PTM
N-glycosylated.
Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
More Infomation

Zhang, Y., & Lui, W. Y. (2021). Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis. Molecular Mechanisms in Spermatogenesis, 95-109.

Han, X., Zhao, Z. A., Yan, S., Lei, W., Wu, H., Lu, X. A., ... & Hu, S. (2020). CXADR‐like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction. Journal of cellular and molecular medicine, 24(23), 13775-13788.

Nilchian, A., Johansson, J., Ghalali, A., Asanin, S. T., Santiago, A., Rosencrantz, O., ... & Fuxe, J. (2019). CXADR-mediated formation of an AKT inhibitory signalosome at tight junctions controls epithelial–mesenchymal plasticity in breast cancer. Cancer Research, 79(1), 47-60.

Kobayashi, T., Matsugo, H., Maruyama, J., Kamiki, H., Takada, A., Maeda, K., ... & Horimoto, T. (2019). Characterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor. Scientific reports, 9(1), 1-13.

Jeong, Y., Ock, S. A., Yoo, J. G., Yu, D. Y., & Choi, I. (2019). The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice. Molecular Reproduction and Development, 86(11), 1628-1638.

Outhwaite, J. E., Patel, J., & Simmons, D. G. (2019). Secondary placental defects in Cxadr mutant mice. Frontiers in physiology, 622.

Kawada, M., Sakamoto, S., Inoue, H., Kaneko, M., Ogasawara, S., Kajikawa, M., ... & Kato, Y. (2019). Abstract B097: Development of a mouse-human chimeric antibody against human CXADR having a potent antitumor activity in animal models.

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For research use only. Not intended for any clinical use.

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