Mouse Anti-CRYGC Recombinant Antibody (1D6) (V2LY-1206-LY1326)

Name: Mouse Anti-CRYGC Recombinant Antibody (1D6)
SKU: V2LY-1206-LY1326
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

1D6

Antibody Isotype

IgG2a

Application

WB, IF

Basic Information

Immunogen

Full length human recombinant protein of human CRYGC produced in HEK293T cell.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:4,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

crystallin, gamma C

Entrez Gene ID

Human	1420
Mouse	12966
Rat	24277

UniProt ID

Human	P07315
Mouse	Q61597
Rat	P02529

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Biological Process

Lens development in camera-type eye Source: GO_Central
Visual perception Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Cataract 2, multiple types (CTRCT2):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye.

More Infomation

References

Zhou, Z., Zhao, L., Guo, Y., Zhuang, J., Zhuo, N., Chen, H., ... & Wang, L. (2022). A Novel Mutation in CRYGC Mutation Associated with Autosomal Dominant Congenital Cataracts and Microcornea. Ophthalmology Science, 2(1), 100093.

Kandaswamy, D. K., Vasantha, K., Graw, J., & Santhiya, S. T. (2020). A novel CRYGC E128* mutation underlying an autosomal dominant nuclear cataract in a south Indian kindred. Ophthalmic Genetics, 41(6), 556-562.

Zhong, Z., Wu, Z., Han, L., & Chen, J. (2017). Novel mutations in CRYGC are associated with congenital cataracts in Chinese families. Scientific reports, 7(1), 1-7.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CRYGC Recombinant Antibody (CBFYC-2255)

Mouse Anti-CRYGC Recombinant Antibody (CBCNC-380)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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