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Mouse Anti-CRNN Recombinant Antibody (CBXC-1735) (V2LY-1206-LY1208)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-1735
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 32-92 mapping near the N-terminus of human cornulin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cornulin
Entrez Gene ID
Human49860
Mouse381457
Rat295186
UniProt ID
HumanQ9UBG3
MouseD3YUU6
RatD3ZSW4
Function
Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832).

Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832).
Biological Process
Cell-cell adhesion Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Positive regulation of cell cycle G1/S phase transition Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Response to heat Source: UniProtKB
Cellular Location
Cytoplasm. Does not colocalize with TGM1.
Involvement in disease
Esophageal cancer (ESCR):
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
More Infomation

Saleem, S., Aleem, I., Atiq, A., Tariq, S., Babar, A., Bakar, M. A., ... & Sutton, C. (2021). Expression of cornulin in tongue squamous cell carcinoma. ecancermedicalscience, 15.

Selvaraj, J., Jh, S. F., Sivabalan, V., Rekha, U. V., Ponnulakshmi, R., Vishnupriya, V., ... & Vijayalakshmi, P. (2021). Molecular modeling of cornulin (CRNN) for docking with phytocompounds from Justicia adhatoda L. Bioinformation, 17(1), 200-205.

Kaur, R., Chauhan, A., Bhat, S. A., Chatterjee, D., Ghoshal, S., & Pal, A. (2021). Gene of the month: Cornulin. Journal of clinical pathology.

Shehata, W. A., Hammam, M. A., Ayad, A., & Holah, N. S. (2021). Immunohistochemical expression of cornulin in lesional and perilesional skin of plaque psoriasis. Journal of cosmetic dermatology.

Li, C., Xiao, L., Jia, J., Li, F., Wang, X., Duan, Q., ... & Zheng, Y. (2019). Cornulin is induced in psoriasis lesions and promotes keratinocyte proliferation via phosphoinositide 3-kinase/Akt pathways. Journal of Investigative Dermatology, 139(1), 71-80.

Sundkvist, A., Myte, R., Bodén, S., Enroth, S., Gyllensten, U., Harlid, S., & van Guelpen, B. (2018). Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff. Scientific reports, 8(1), 1-10.

Trzeciak, M., Sakowicz-Burkiewicz, M., Wesserling, M., Gleń, J., Dobaczewska, D., Bandurski, T., ... & Pawelczyk, T. (2017). Altered expression of genes encoding cornulin and repetin in atopic dermatitis. International archives of allergy and immunology, 172(1), 11-19.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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