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Mouse Anti-CRADD Recombinant Antibody (CBYY-C2839) (V2LY-1206-LY1074)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2839
Antibody Isotype
IgG2b, κ
Application
WB, IF, IHC, ELISA

Basic Information

Immunogen
Recombinant CRADD (Met1-Glu199) expressed in E Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA0.5-2 µg/ml
WB0.5-2 µg/ml
IF(ICC)5-20 µg/ml
IHC5-20 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CASP2 and RIPK1 domain containing adaptor with death domain
Entrez Gene ID
8738
UniProt ID
P78560
Function
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572).

Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253).
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Apoptotic signaling pathway Source: UniProtKB
Cellular response to mechanical stimulus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
Extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: GO_Central
Regulation of apoptotic process Source: Reactome
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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